Literature DB >> 18801697

Therapeutic prospects for p73 and p63: rising from the shadow of p53.

Anna Vilgelm1, Wael El-Rifai, Alexander Zaika.   

Abstract

The p53 protein family consists of three transcription factors: p53, p63, and p73. These proteins share significant structural and functional similarities and each has unique biological functions as well. Although the role of p53 in cellular stress is extensively studied, many questions remain about p63 and p73. In this review we summarize current data on functional interactions within the p53 family, their regulation and roles in response to genotoxic stress. We also discuss the significance of p73 and p63 for cancer therapy and outline novel approaches in development of therapeutic drugs that specifically target the p53 family.

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Year:  2008        PMID： 18801697      PMCID： PMC2585826          DOI： 10.1016/j.drup.2008.08.001

Source DB:  PubMed          Journal:  Drug Resist Updat        ISSN： 1368-7646            Impact factor:   18.500


  145 in total

1.  Lack of p73 expression in mature B-ALL and identification of three new splicing variants restricted to pre B and C-ALL indicate a role of p73 in B cell ALL differentiation.

Authors:  P Scaruffi; I Casciano; L Masiero; G Basso; M Romani; G P Tonini
Journal:  Leukemia       Date:  2000-03       Impact factor: 11.528

2.  p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation.

Authors:  I Katoh; K I Aisaki; S I Kurata; S Ikawa; Y Ikawa
Journal:  Oncogene       Date:  2000-06-22       Impact factor: 9.867

3.  p73 is transcriptionally regulated by DNA damage, p53, and p73.

Authors:  X Chen; Y Zheng; J Zhu; J Jiang; J Wang
Journal:  Oncogene       Date:  2001-02-08       Impact factor: 9.867

4.  Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains.

Authors:  X Espanel; M Sudol
Journal:  J Biol Chem       Date:  2001-01-31       Impact factor: 5.157

5.  A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.

Authors:  C Gaiddon; M Lokshin; J Ahn; T Zhang; C Prives
Journal:  Mol Cell Biol       Date:  2001-03       Impact factor: 4.272

6.  Role of the p53-homologue p73 in E2F1-induced apoptosis.

Authors:  T Stiewe; B M Pützer
Journal:  Nat Genet       Date:  2000-12       Impact factor: 38.330

7.  p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours.

Authors:  A Yang; N Walker; R Bronson; M Kaghad; M Oosterwegel; J Bonnin; C Vagner; H Bonnet; P Dikkes; A Sharpe; F McKeon; D Caput
Journal:  Nature       Date:  2000-03-02       Impact factor: 49.962

8.  An anti-apoptotic role for the p53 family member, p73, during developmental neuron death.

Authors:  C D Pozniak; S Radinovic; A Yang; F McKeon; D R Kaplan; F D Miller
Journal:  Science       Date:  2000-07-14       Impact factor: 47.728

9.  Role for the p53 homologue p73 in E2F-1-induced apoptosis.

Authors:  M Irwin; M C Marin; A C Phillips; R S Seelan; D I Smith; W Liu; E R Flores; K Y Tsai; T Jacks; K H Vousden; W G Kaelin
Journal:  Nature       Date:  2000-10-05       Impact factor: 49.962

10.  Physical interaction with Yes-associated protein enhances p73 transcriptional activity.

Authors:  S Strano; E Munarriz; M Rossi; L Castagnoli; Y Shaul; A Sacchi; M Oren; M Sudol; G Cesareni; G Blandino
Journal:  J Biol Chem       Date:  2001-01-24       Impact factor: 5.157
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  30 in total

Review 1.  Role of the nucleus in apoptosis: signaling and execution.

Authors:  Evgeniia A Prokhorova; Alexey V Zamaraev; Gelina S Kopeina; Boris Zhivotovsky; Inna N Lavrik
Journal:  Cell Mol Life Sci       Date:  2015-09-07       Impact factor: 9.261

2.  The association between non-Hodgkin lymphoma and methylation of p73.

Authors:  Jing-Hong Pei; Sai-Qun Luo; Yan Zhong; Jiang-Hua Chen; Hua-Wu Xiao; Wei-Xin Hu
Journal:  Tumour Biol       Date:  2011-08-03

Review 3.  Expression of p53 in upper urinary tract urothelial carcinoma.

Authors:  Stephen Mitchell; Erik Mayer; Anup Patel
Journal:  Nat Rev Urol       Date:  2011-08-02       Impact factor: 14.432

4.  Characterization of ΔNp73 expression and regulation in gastric and esophageal tumors.

Authors:  A E Vilgelm; S-M Hong; M K Washington; J Wei; H Chen; W El-Rifai; A Zaika
Journal:  Oncogene       Date:  2010-08-02       Impact factor: 9.867

5.  Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute myeloid leukemia cells.

Authors:  Juni Chakraborty; Shuvomoy Banerjee; Pallab Ray; Dewan Md Sakib Hossain; Sankar Bhattacharyya; Arghya Adhikary; Sreya Chattopadhyay; Tanya Das; Gaurisankar Sa
Journal:  J Biol Chem       Date:  2010-07-30       Impact factor: 5.157

6.  The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation.

Authors:  Yong-Sam Jung; Yingjuan Qian; Xinbin Chen
Journal:  J Biol Chem       Date:  2011-08-18       Impact factor: 5.157

7.  MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6.

Authors:  Declan J McKenna; Simon S McDade; Daksha Patel; Dennis J McCance
Journal:  J Virol       Date:  2010-08-11       Impact factor: 5.103

8.  A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma.

Authors:  Benjamin Ory; Matthew R Ramsey; Catherine Wilson; Douangsone D Vadysirisack; Nicole Forster; James W Rocco; S Michael Rothenberg; Leif W Ellisen
Journal:  J Clin Invest       Date:  2011-02       Impact factor: 14.808

9.  TAp73 induction by nitric oxide: regulation by checkpoint kinase 1 (CHK1) and protection against apoptosis.

Authors:  Ali Tebbi; Olivier Guittet; Marie-Hélène Cottet; Marie-Françoise Vesin; Michel Lepoivre
Journal:  J Biol Chem       Date:  2011-01-06       Impact factor: 5.157

10.  ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes.

Authors:  Edgardo R Parrilla Castellar; Elaine S Jaffe; Jonathan W Said; Steven H Swerdlow; Rhett P Ketterling; Ryan A Knudson; Jagmohan S Sidhu; Eric D Hsi; Shridevi Karikehalli; Liuyan Jiang; George Vasmatzis; Sarah E Gibson; Sarah Ondrejka; Alina Nicolae; Karen L Grogg; Cristine Allmer; Kay M Ristow; Wyndham H Wilson; William R Macon; Mark E Law; James R Cerhan; Thomas M Habermann; Stephen M Ansell; Ahmet Dogan; Matthew J Maurer; Andrew L Feldman
Journal:  Blood       Date:  2014-06-03       Impact factor: 22.113
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