| Literature DB >> 18800793 |
Robert M Haak1, Florian Berthiol, Thomas Jerphagnon, Arnaud J A Gayet, Chiara Tarabiono, Christiaan P Postema, Vincent Ritleng, Michel Pfeffer, Dick B Janssen, Adriaan J Minnaard, Ben L Feringa, Johannes G de Vries.
Abstract
The direct chemo-enzymatic DKR of racemic beta-haloalcohols is reported, yielding the corresponding optically active epoxides in a single step. The mutant haloalcohol dehalogenase HheC Cys153Ser Trp249Phe is used for the asymmetric ring closure, whereas racemization of the remaining enantiomer of the haloalcohol is achieved using the new iridacycle 3, one of the most effective racemization catalysts to date for beta-haloalcohols.Entities:
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Year: 2008 PMID： 18800793 DOI： 10.1021/ja805128x
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419