Literature DB >> 1880068

Inactivation of fusidic acid by resistant Streptomyces strains.

B von der Haar1, D Rosenberg, W Dittrich, H Schrempf.   

Abstract

Streptomyces lividans and several other Streptomyces species are resistant to the steroid-like antibiotic fusidic acid. This resistance is mediated by structural modification of the antibiotic. Using TLC, CD, UV, IR, NMR and mass spectroscopy the structure of one of the resulting inactive compounds was determined. It is derived from fusidic acid by the loss of an acetyl group and the formation of a lactone ring between C-21 and C-16. In addition, helvolic acid, a compound closely related to fusidic acid, has been shown to be modified.

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Year:  1991        PMID： 1880068     DOI： 10.7164/antibiotics.44.785

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  3 in total

1.  Purification and characterization of a novel extracellular Streptomyces lividans 66 enzyme inactivating fusidic acid.

Authors:  B von der Haar; H Schrempf
Journal:  J Bacteriol       Date:  1995-01       Impact factor: 3.490

2.  Total Synthesis of Tetrahydrolipstatin, Its Derivatives, and Evaluation of Their Ability to Potentiate Multiple Antibiotic Classes against Mycobacterium Species.

Authors:  Saniya S Khan; Thanuja D Sudasinghe; Alexander D Landgraf; Donald R Ronning; Steven J Sucheck
Journal:  ACS Infect Dis       Date:  2021-09-03       Impact factor: 5.578

3.  The unstable tetracycline resistance gene of Streptomyces lividans 1326 encodes a putative protein with similarities to translational elongation factors and Tet(M) and Tet(O) proteins.

Authors:  W Dittrich; H Schrempf
Journal:  Antimicrob Agents Chemother       Date:  1992-05       Impact factor: 5.191
  3 in total

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