OBJECTIVE: To test the hypothesis that Type-D personality is associated with elevated cortisol levels in patients 4 months after an acute coronary syndrome (ACS). METHODS: Salivary cortisol profiles were measured at home in 70 coronary heart disease patients (Mean age = 60.90 years, SD = 10.7, 17% female) 4 months after hospitalization for ACS. Eight saliva samples were taken over the course of 1 day. RESULTS: Thirty eight percent of the ACS patients were defined as Type-D. Cortisol profiles showed a typical diurnal pattern, with low levels in the evening, high levels early in the day. Type-D was not related to the cortisol awakening response, but cortisol output the day was higher in Type-D (mean = 4443.3, SD = 2334.1 nmol/l) than non Type-D patients (mean = 3252.0, SD = 1810.2 nmol/l) after adjustment for age, gender, hypertension, Global Registry of Acute Coronary Events risk score, recurrence of cardiac symptoms, previous myocardial infarction, body mass index and concurrent depressed mood (p = .044). Type-D personality accounted for 6% over the variance in cortisol output over the day, after covariates had been taken into account. CONCLUSION: Type-D personality may be associated with prolonged disruption of the hypothalamic-pituitary-adrenal axis function in survivors of acute cardiac events and may contribute to biological responses influencing future cardiac morbidity.
OBJECTIVE: To test the hypothesis that Type-D personality is associated with elevated cortisol levels in patients 4 months after an acute coronary syndrome (ACS). METHODS: Salivary cortisol profiles were measured at home in 70 coronary heart diseasepatients (Mean age = 60.90 years, SD = 10.7, 17% female) 4 months after hospitalization for ACS. Eight saliva samples were taken over the course of 1 day. RESULTS: Thirty eight percent of the ACS patients were defined as Type-D. Cortisol profiles showed a typical diurnal pattern, with low levels in the evening, high levels early in the day. Type-D was not related to the cortisol awakening response, but cortisol output the day was higher in Type-D (mean = 4443.3, SD = 2334.1 nmol/l) than non Type-D patients (mean = 3252.0, SD = 1810.2 nmol/l) after adjustment for age, gender, hypertension, Global Registry of Acute Coronary Events risk score, recurrence of cardiac symptoms, previous myocardial infarction, body mass index and concurrent depressed mood (p = .044). Type-D personality accounted for 6% over the variance in cortisol output over the day, after covariates had been taken into account. CONCLUSION: Type-D personality may be associated with prolonged disruption of the hypothalamic-pituitary-adrenal axis function in survivors of acute cardiac events and may contribute to biological responses influencing future cardiac morbidity.
Authors: Kavita Vedhara; Sana Gill; Lameese Eldesouky; Bruce K Campbell; Jesusa M G Arevalo; Jeffrey Ma; Steven W Cole Journal: Psychoneuroendocrinology Date: 2014-11-11 Impact factor: 4.905
Authors: Erla Svansdottir; Hrobjartur D Karlsson; Thorarinn Gudnason; Daniel T Olason; Hordur Thorgilsson; Unnur Sigtryggsdottir; Eric J Sijbrands; Susanne S Pedersen; Johan Denollet Journal: J Behav Med Date: 2011-04-28
Authors: Marja J H van Bon-Martens; Johan Denollet; Lambertus A L M Kiemeney; Mariël Droomers; Monique J A de Beer; Ien A M van de Goor; Hans A M van Oers Journal: BMC Public Health Date: 2012-01-18 Impact factor: 3.295