OBJECTIVE: The objective of the study was to identify epidemiological correlates for persistence and clearance of human papillomavirus (HPV) infection. STUDY DESIGN: Cervical smears collected in a prospective cohort study to perform Papanicoloau cytology and HPV deoxyribonucleic acid (DNA) detection at baseline and during the follow-up. Outcomes analyzed were: (1) persistence of HPV DNA; (2) conversion; and (3) clearance of HPV. RESULTS: Among 501 women the incidence of HPV was 12.3%. Thirty-four women were persistently infected with HPV, which was associated with age below 21 years at first intercourse and 4 or more sexual partners during their lifetime. In a median of 19 months, 80.7% of women had clearance of HPV, which was associated with black race, coinfection with Chlamydia trachomatis at baseline, and a history of previous Papanicoloau smear. CONCLUSION: Strategies for sexual orientation may modify the rates of HPV persistence. The association of HPV clearance with a history of previous Papanicolaou smear screening highlights the importance of improving cervical screening programs. Further studies on the association of gynecological infections with HPV clearance are needed.
OBJECTIVE: The objective of the study was to identify epidemiological correlates for persistence and clearance of human papillomavirus (HPV) infection. STUDY DESIGN: Cervical smears collected in a prospective cohort study to perform Papanicoloau cytology and HPV deoxyribonucleic acid (DNA) detection at baseline and during the follow-up. Outcomes analyzed were: (1) persistence of HPV DNA; (2) conversion; and (3) clearance of HPV. RESULTS: Among 501 women the incidence of HPV was 12.3%. Thirty-four women were persistently infected with HPV, which was associated with age below 21 years at first intercourse and 4 or more sexual partners during their lifetime. In a median of 19 months, 80.7% of women had clearance of HPV, which was associated with black race, coinfection with Chlamydia trachomatis at baseline, and a history of previous Papanicoloau smear. CONCLUSION: Strategies for sexual orientation may modify the rates of HPV persistence. The association of HPV clearance with a history of previous Papanicolaou smear screening highlights the importance of improving cervical screening programs. Further studies on the association of gynecological infections with HPV clearance are needed.
Authors: Nadja Vielot; Michael G Hudgens; Nelly Mugo; Michael Chitwa; Joshua Kimani; Jennifer Smith Journal: Sex Transm Dis Date: 2015-06 Impact factor: 2.830
Authors: Erin M Siegel; Nitin Patel; Beibei Lu; Ji-Hyun Lee; Alan G Nyitray; Neal E Craft; Krystyna Frenkel; Luisa L Villa; Eduardo L Franco; Anna R Giuliano Journal: Int J Cancer Date: 2011-11-28 Impact factor: 7.396
Authors: Karolina Louvanto; Kari J Syrjänen; Marjut A M Rintala; Seija E Grénman; Stina M Syrjänen Journal: J Clin Microbiol Date: 2010-06-16 Impact factor: 5.948
Authors: Anne F Rositch; Jill Koshiol; Michael G Hudgens; Hilda Razzaghi; Danielle M Backes; Jeanne M Pimenta; Eduardo L Franco; Charles Poole; Jennifer S Smith Journal: Int J Cancer Date: 2012-10-11 Impact factor: 7.396
Authors: Alyce A Chen; Daniëlle A M Heideman; Debby Boon; Zigui Chen; Robert D Burk; Hugo De Vuyst; Tarik Gheit; Peter J F Snijders; Massimo Tommasino; Silvia Franceschi; Gary M Clifford Journal: Virology Date: 2013-11-12 Impact factor: 3.616
Authors: Michelle Oliveira-Silva; Camila X Lordello; Lucília M G Zardo; Cibele R Bonvicino; Miguel A M Moreira Journal: Virol J Date: 2011-01-05 Impact factor: 4.099
Authors: I G S S Serra; E D Araujo; G S Barros; F L S G Santos; R Q Gurgel; M V A Batista Journal: Epidemiol Infect Date: 2018-05-21 Impact factor: 4.434