| Literature DB >> 18798636 |
Ramakrishnan Vallinayagam1, Joanne Weber, Reinhard Neier.
Abstract
5-Aminolevulinic acid (ALA) and derivatives thereof have been successfully used in photodynamic cancer therapy (PDT). The synthesis of novel bioconjugates combining ALA with two lipophilic and one hydrophilic vitamins is reported. The new bioconjugates allow studying the potential synergies between the two components in PDT. The synthetic methodology is robust giving the bioconjugates in good to satisfactory yield.Entities:
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Year: 2008 PMID： 18798636 DOI： 10.1021/ol801496j
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005