Literature DB >> 18797139

No relationship exists between PBP 2a amounts expressed in different MRSA strains obtained clinically and their beta-lactam MIC values.

Md Anowar Khasru Parvez1, Hirofumi Shibata, Tatsuro Nakano, Shingo Niimi, Nobuo Fujii, Naokatu Arakaki, Tomihiko Higuti.   

Abstract

After establishing a linear relationship between the amount of penicillin-binding protein (PBP) 2a and membrane proteins of methicillin-resistant Staphylococcus aureus (MRSA) COL by dot-blot analysis using an antibody against PBP 2a, we determined the PBP 2a quantities in membrane fractions prepared from 14 different MRSA cells. Methicillin-sensitive S. aureus ATCC 6538P was used as a quality control strain. The amounts of PBP 2a diverged among the strains, and no relationship to beta-lactam MIC values were observed in the corresponding strains.

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Year:  2008        PMID： 18797139     DOI： 10.2152/jmi.55.246

Source DB:  PubMed          Journal:  J Med Invest        ISSN： 1343-1420


  6 in total

Review 1.  Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge.

Authors:  Leticia I Llarrull; Jed F Fisher; Shahriar Mobashery
Journal:  Antimicrob Agents Chemother       Date:  2009-05-26       Impact factor: 5.191

2.  Dalbavancin Alone and in Combination with Ceftaroline against Four Different Phenotypes of Staphylococcus aureus in a Simulated Pharmacodynamic/Pharmacokinetic Model.

Authors:  Razieh Kebriaei; Seth A Rice; Kyle C Stamper; Michael J Rybak
Journal:  Antimicrob Agents Chemother       Date:  2019-03-27       Impact factor: 5.191

3.  Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae.

Authors:  K Kosowska-Shick; P L McGhee; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  2010-03-01       Impact factor: 5.191

4.  Rapid identification and antibiotic susceptibility test of pathogens in blood based on magnetic separation and surface-enhanced Raman scattering.

Authors:  Jia Li; Chongwen Wang; Luoluo Shi; Liting Shao; Peiwen Fu; Keli Wang; Rui Xiao; Shengqi Wang; Bing Gu
Journal:  Mikrochim Acta       Date:  2019-06-27       Impact factor: 5.833

5.  The Sle1 Cell Wall Amidase Is Essential for β-Lactam Resistance in Community-Acquired Methicillin-Resistant Staphylococcus aureus USA300.

Authors:  Ida Thalsø-Madsen; Fernando Ruiz Torrubia; Lijuan Xu; Andreas Petersen; Camilla Jensen; Dorte Frees
Journal:  Antimicrob Agents Chemother       Date:  2019-12-20       Impact factor: 5.191

6.  β-Lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease.

Authors:  Kristoffer T Bæk; Angelika Gründling; René G Mogensen; Louise Thøgersen; Andreas Petersen; Wilhelm Paulander; Dorte Frees
Journal:  Antimicrob Agents Chemother       Date:  2014-05-27       Impact factor: 5.191
  6 in total

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