Literature DB >> 187964

Comparative studies on isolated rat hepatocytes and AS-30D hepatoma cells with leucocidin from Pseudomonas aeruginosa.

M Frimmer, J Homann, E Petzinger, U Rufeger, W Scharmann.   

Abstract

Leucocidin, one of the cytotoxic principles of Pseudomonas aeruginosa induces potassium loss and swelling in isolated hepatocytes and in AS-30D ascites hepatoma cells in a dose and time dependent manner. Hepatoma cells are more sensitive than normal hepatocytes. As shown by scanning electron microscopy the volume increase of both types of cells is accompanied by disappearance of microvilli. In contrast to phalloidin poisoning no protrusions were formed when the cells were exposed to leucocidin under isotonic conditions.

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Year:  1976        PMID： 187964     DOI： 10.1007/bf00509774

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  9 in total

1.  THE INFLUENCE OF BUFFER SYSTEMS ON FIXATION WITH OSMIUM TETROXIDE.

Authors:  R L WOOD; J H LUFT
Journal:  J Ultrastruct Res       Date:  1965-02

2.  Staphylococcal leucocidins.

Authors:  G P GLADSTONE; W E VAN HEYNINGEN
Journal:  Br J Exp Pathol       Date:  1957-04

3.  Electron microscopy of isolated rat hepatocytes before and after treatment with phalloidin.

Authors:  E Weiss; I Sterz; M Frimmer; R Kroker
Journal:  Beitr Pathol       Date:  1973-12

4.  The role of extracellular K plus-concentration in phalloidin effects on isolated hepatocytes and perfused rat livers.

Authors:  M Frimmer; R Kroker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

5.  The mode of action of phalloidin: demonstration of rapid deformation of isolated hepatocytes by scanning electron microscopy.

Authors:  M Frimmer; R Kroker; J Porstendörfer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

6.  Toxicity of a highly purified leucocidin from Pseudomonas aeruginosa in perfused rat livers.

Authors:  M Frimmer; W Scharmann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

7.  Leucocidin from Pseudomonas aeruginosa and membrane functions.

Authors:  D Hegner; A Petter; R Kroker; M S Anwer; W Scharmann; V Breuninger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976       Impact factor: 3.000

8.  Role of microvilli in surface changes of synchronized P815Y mastocytoma cells.

Authors:  S Knutton; M C Sumner; C A Pasternak
Journal:  J Cell Biol       Date:  1975-09       Impact factor: 10.539

9.  High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.

Authors:  M N Berry; D S Friend
Journal:  J Cell Biol       Date:  1969-12       Impact factor: 10.539
  9 in total
  14 in total

1.  Interaction of Pseudomonas aeruginosa cytotoxin with plasma membranes from Ehrlich ascites tumor cells.

Authors:  F Lutz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-01       Impact factor: 3.000

2.  Pulmonary microvascular injury induced by Pseudomonas aeruginosa cytotoxin in isolated rabbit lungs.

Authors:  W Seeger; D Walmrath; H Neuhof; F Lutz
Journal:  Infect Immun       Date:  1986-06       Impact factor: 3.441

3.  The role of plasma membranes in hepatotoxic effects.

Authors:  M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977       Impact factor: 3.000

4.  A cytotoxin of Pseudomonas aeruginosa acts directly on the cortical thick ascending limb of Henle's loop of rabbit kidney.

Authors:  R N Weiner; R Greger; E Schlatter; F Papavassiliou; K J Ullrich
Journal:  Pflugers Arch       Date:  1982-09       Impact factor: 3.657

5.  Transient desensibilization of isolated hepatocytes against phalloidin by treatment with phospholipase A.

Authors:  E Petzinger; U Rufeger; M Frimmer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978 Jan-Feb       Impact factor: 3.000

6.  A possible reason for the phalloidin tolerance of hepatoma cells.

Authors:  E Grundmann; E Petzinger; M Frimmer; C B Boschek
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-12       Impact factor: 3.000

7.  Effect of Pseudomonas aeruginosa cytotoxin on thymidine incorporation by murine splenocytes.

Authors:  T G Obrig; A L Baltch; T P Moran; S P Mudzinski; R P Smith; F Lutz
Journal:  Infect Immun       Date:  1984-09       Impact factor: 3.441

8.  [Isolated liver cells of the rat under the influence of a toxic factor from burnt human and animal skin (author's transl)].

Authors:  J Schölmerich; B Kremer; K Schmidt; H Setyadharma; I E Richter; G A Schoenenberger
Journal:  Langenbecks Arch Chir       Date:  1980

9.  Chemical modification of membrane proteins by brominated taurodehydrocholate in isolated hepatocytes; relationship to the uptake of cholate and of phalloidin and to the sensitivity of hepatocytes to phalloidin.

Authors:  K Ziegler; M Frimmer; W Möller; H Fasold
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-06       Impact factor: 3.000

10.  Permeability changes of Ehrlich mouse ascites tumor cells induced by a cytotoxin from Pseudomonas aeruginosa.

Authors:  F Lutz; S Grieshaber; K Schmidt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-07       Impact factor: 3.000
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