| Literature DB >> 18794854 |
W H Linda Kao1, Michael J Klag, Lucy A Meoni, David Reich, Yvette Berthier-Schaad, Man Li, Josef Coresh, Nick Patterson, Arti Tandon, Neil R Powe, Nancy E Fink, John H Sadler, Matthew R Weir, Hanna E Abboud, Sharon G Adler, Jasmin Divers, Sudha K Iyengar, Barry I Freedman, Paul L Kimmel, William C Knowler, Orly F Kohn, Kristopher Kramp, David J Leehey, Susanne B Nicholas, Madeleine V Pahl, Jeffrey R Schelling, John R Sedor, Denyse Thornley-Brown, Cheryl A Winkler, Michael W Smith, Rulan S Parekh.
Abstract
As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.Entities:
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Year: 2008 PMID： 18794854 PMCID： PMC2614692 DOI： 10.1038/ng.232
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330