Literature DB >> 18794072

Advances in targeting IKK and IKK-related kinases for cancer therapy.

Dung-Fang Lee1, Mien-Chie Hung.   

Abstract

IkappaB kinases (IKK) and IKK-related kinases play critical roles in regulating the immune response through nuclear factor-kappaB and IFN regulatory factor-dependent signaling transduction cascades. Recently, these kinases have been implicated in the pathogenesis of many human diseases, including cancer. In fact, dysregulation of IKK activities promotes tumor survival, proliferation, migration, metastasis, and angiogenesis-common characteristics of many types of human cancers. Because of their oncogenic effects in human cancer development, targeting IKK and IKK-related kinases is becoming an increasingly popular avenue for the development of novel therapeutic interventions for cancer. This review will briefly cover the recent discovery of the downstream substrates of IKK and IKK-related kinases, and outline the strategies used for targeting IKK as a therapeutic intervention for cancer.

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Year:  2008        PMID： 18794072      PMCID： PMC2613770          DOI： 10.1158/1078-0432.CCR-08-0123

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  61 in total

1.  Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation.

Authors:  Kyu-Jin Park; Venkatesh Krishnan; Bert W O'Malley; Yumi Yamamoto; Richard B Gaynor
Journal:  Mol Cell       Date:  2005-04-01       Impact factor: 17.970

2.  IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.

Authors:  T Shimada; T Kawai; K Takeda; M Matsumoto; J Inoue; Y Tatsumi; A Kanamaru; S Akira
Journal:  Int Immunol       Date:  1999-08       Impact factor: 4.823

3.  NAK is an IkappaB kinase-activating kinase.

Authors:  Y Tojima; A Fujimoto; M Delhase; Y Chen; S Hatakeyama; K Nakayama; Y Kaneko; Y Nimura; N Motoyama; K Ikeda; M Karin; M Nakanishi
Journal:  Nature       Date:  2000-04-13       Impact factor: 49.962

4.  E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IkappaB kinases and nuclear factor kappaB activities.

Authors:  R Shao; M C Hu; B P Zhou; S Y Lin; P J Chiao; R H von Lindern; B Spohn; M C Hung
Journal:  J Biol Chem       Date:  1999-07-30       Impact factor: 5.157

5.  IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation.

Authors:  Sanghoon Lee; Charlotte Andrieu; Frédéric Saltel; Olivier Destaing; Jessie Auclair; Véronique Pouchkine; Jocelyne Michelon; Bruno Salaun; Ryuji Kobayashi; Pierre Jurdic; Elliott D Kieff; Bakary S Sylla
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-01       Impact factor: 11.205

6.  IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.

Authors:  Mickey C-T Hu; Dung-Fang Lee; Weiya Xia; Leonard S Golfman; Fu Ou-Yang; Jer-Yen Yang; Yiyu Zou; Shilai Bao; Norihisa Hanada; Hitomi Saso; Ryuji Kobayashi; Mien-Chie Hung
Journal:  Cell       Date:  2004-04-16       Impact factor: 41.582

7.  Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of IKK activity.

Authors:  Lone Stengelshøj Olsen; Pernille-Julia Vig Hjarnaa; Scilla Latini; Pernille Kaae Holm; Rolf Larsson; Erik Bramm; Lise Binderup; Mogens Winkel Madsen
Journal:  Int J Cancer       Date:  2004-08-20       Impact factor: 7.396

8.  IkappaB kinase is an essential component of the Tpl2 signaling pathway.

Authors:  Michael Waterfield; Wei Jin; William Reiley; Minying Zhang; Shao-Cong Sun
Journal:  Mol Cell Biol       Date:  2004-07       Impact factor: 4.272

9.  Activation of LPS-inducible genes by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid in primary murine macrophages. Dissection of signaling pathways leading to gene induction and tyrosine phosphorylation.

Authors:  P Y Perera; S A Barber; L M Ching; S N Vogel
Journal:  J Immunol       Date:  1994-11-15       Impact factor: 5.422

10.  The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.

Authors:  Hiroaki Hemmi; Osamu Takeuchi; Shintaro Sato; Masahiro Yamamoto; Tsuneyasu Kaisho; Hideki Sanjo; Taro Kawai; Katsuaki Hoshino; Kiyoshi Takeda; Shizuo Akira
Journal:  J Exp Med       Date:  2004-06-21       Impact factor: 14.307
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  54 in total

1.  Blocking IKKα expression inhibits prostate cancer invasiveness.

Authors:  Rubi Mahato; Bin Qin; Kun Cheng
Journal:  Pharm Res       Date:  2010-12-30       Impact factor: 4.200

2.  Hypoxia and cytokines regulate carbonic anhydrase 9 expression in hepatocellular carcinoma cells in vitro.

Authors:  Feray Kockar; Hatice Yildrim; Rahsan Ilikci Sagkan; Carsten Hagemann; Yasemin Soysal; Jelena Anacker; Ahmed Ayad Hamza; Dirk Vordermark; Michael Flentje; Harun M Said
Journal:  World J Clin Oncol       Date:  2012-06-10

Review 3.  Emerging roles for the non-canonical IKKs in cancer.

Authors:  R R Shen; W C Hahn
Journal:  Oncogene       Date:  2010-11-01       Impact factor: 9.867

4.  IKKα takes control of canonical NF-κB activation.

Authors:  Christiane Pelzer; Margot Thome
Journal:  Nat Immunol       Date:  2011-08-18       Impact factor: 25.606

5.  Insights into the genomic landscape of MYD88 wild-type Waldenström macroglobulinemia.

Authors:  Zachary R Hunter; Lian Xu; Nickolas Tsakmaklis; Maria G Demos; Amanda Kofides; Cristina Jimenez; Gloria G Chan; Jiaji Chen; Xia Liu; Manit Munshi; Joshua Gustine; Kirsten Meid; Christopher J Patterson; Guang Yang; Toni Dubeau; Mehmet K Samur; Jorge J Castillo; Kenneth C Anderson; Nikhil C Munshi; Steven P Treon
Journal:  Blood Adv       Date:  2018-11-13

6.  Tumor necrosis factor-{alpha} suppresses angiotensinogen expression through formation of a p50/p50 homodimer in human renal proximal tubular cells.

Authors:  Ryousuke Satou; Kayoko Miyata; Akemi Katsurada; L Gabriel Navar; Hiroyuki Kobori
Journal:  Am J Physiol Cell Physiol       Date:  2010-06-30       Impact factor: 4.249

Review 7.  Signaling cross-talk in the resistance to HER family receptor targeted therapy.

Authors:  H Yamaguchi; S-S Chang; J L Hsu; M-C Hung
Journal:  Oncogene       Date:  2013-04-01       Impact factor: 9.867

8.  A splicing variant of NME1 negatively regulates NF-κB signaling and inhibits cancer metastasis by interacting with IKKβ.

Authors:  Dong-Joo You; Cho Rong Park; Hyun Bok Lee; Mi Jin Moon; Ju-Hee Kang; Cheolju Lee; Seong-Hyun Oh; Curie Ahn; Jae Young Seong; Jong-Ik Hwang
Journal:  J Biol Chem       Date:  2014-05-08       Impact factor: 5.157

9.  BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by selective inhibition of homologous recombinational repair of DNA double-strand breaks.

Authors:  Lixian Wu; Lijian Shao; Manna Li; Junying Zheng; Junru Wang; Wei Feng; Jianhui Chang; Yan Wang; Martin Hauer-Jensen; Daohong Zhou
Journal:  Radiat Res       Date:  2012-12-21       Impact factor: 2.841

10.  TNFalpha induces HIF-1alpha expression through activation of IKKbeta.

Authors:  Hsu-Ping Kuo; Dung-Fang Lee; Weiya Xia; Yongkun Wei; Mien-Chie Hung
Journal:  Biochem Biophys Res Commun       Date:  2009-09-17       Impact factor: 3.575
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