Literature DB >> 18793852

Novel design principle validated: glucopyranosylidene-spiro-oxathiazole as new nanomolar inhibitor of glycogen phosphorylase, potential antidiabetic agent.

László Somsák1, Veronika Nagy, Sébastien Vidal, Katalin Czifrák, Eszter Berzsényi, Jean-Pierre Praly.   

Abstract

2-Naphthyl-substituted glucopyranosylidene-spiro-oxathiazole prepared following a novel design principle was found to be the best known glucose analogue inhibitor of rabbit muscle glycogen phosphorylase b (K(i) 160 nM).

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Year:  2008        PMID: 18793852     DOI: 10.1016/j.bmcl.2008.08.052

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Glucopyranosylidene-Spiro-Thiazolinones: Synthetic Studies and Determination of Absolute Configuration by TDDFT-ECD Calculations.

Authors:  Katalin E Szabó; Sándor Kun; Attila Mándi; Tibor Kurtán; László Somsák
Journal:  Molecules       Date:  2017-10-19       Impact factor: 4.411

  1 in total

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