| Literature DB >> 18793846 |
Guobao Zhang1, Pingda Ren, Nathanael S Gray, Taebo Sim, Yi Liu, Xia Wang, Jianwei Che, Shin-Shay Tian, Mark L Sandberg, Tracy A Spalding, Russell Romeo, Maya Iskandar, Donald Chow, H Martin Seidel, Donald S Karanewsky, Yun He.
Abstract
A series of 4-amino-6-benzimidazole-pyrimidines was designed to target lymphocyte-specific tyrosine kinase (Lck), a member of the Src kinase family. Highly efficient parallel syntheses were devised to prepare analogues for SAR studies. A number of these 4-amino-6-benzimidazole-pyrimidines exhibited single-digit nanomolar IC(50)s against Lck in biochemical and cellular assays. These 4-amino-6-benzimidazole-pyrimidines represent a new class of tyrosine kinase inhibitors.Entities:
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Year: 2008 PMID： 18793846 DOI： 10.1016/j.bmcl.2008.08.104
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823