Literature DB >> 18792872

Modulation of insulin action by advanced glycation endproducts: a new player in the field.

C G Schalkwijk1, O Brouwers, C D A Stehouwer.   

Abstract

Insulin resistance is characterized by an impaired responsiveness to the action of insulin at its multiple target organs. The accumulation of advanced glycation endproducts (AGEs) has been demonstrated in clinical settings of insulin resistance such as in diabetes, hypertension, and obesity. In this review we have focused on advanced glycation as a modulator of insulin resistance. Structural and functional abnormalities of the insulin molecule by glycation and methylglyoxal may contribute to the pathogenesis of insulin resistance. In addition, it is likely that AGEs interfere in the complex molecular pathways of insulin signaling and as such in insulin resistance.

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Year:  2008        PMID： 18792872     DOI： 10.1055/s-0028-1082085

Source DB:  PubMed          Journal:  Horm Metab Res        ISSN： 0018-5043            Impact factor:   2.936


  15 in total

1.  Characterisation of glyoxalase I in a streptozocin-induced mouse model of diabetes with painful and insensate neuropathy.

Authors:  M M Jack; J M Ryals; D E Wright
Journal:  Diabetologia       Date:  2011-06-03       Impact factor: 10.122

Review 2.  Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy.

Authors:  Megan Jack; Douglas Wright
Journal:  Transl Res       Date:  2012-01-10       Impact factor: 7.012

3.  The strong relation between post-hemodialysis blood methylglyoxal levels and post-hemodialysis blood glucose concentration rise.

Authors:  Miho Senda; Susumu Ogawa; Kazuhiro Nako; Masashi Okamura; Takuya Sakamoto; Sadayoshi Ito
Journal:  Clin Exp Nephrol       Date:  2014-08-20       Impact factor: 2.801

4.  Diabetes and cancer: Looking at the multiligand/RAGE axis.

Authors:  Armando Rojas; Ileana González; Erik Morales; Ramón Pérez-Castro; Jacqueline Romero; Héctor Figueroa
Journal:  World J Diabetes       Date:  2011-07-15

Review 5.  Methylglyoxal, obesity, and diabetes.

Authors:  Paulo Matafome; Cristina Sena; Raquel Seiça
Journal:  Endocrine       Date:  2012-09-16       Impact factor: 3.633

6.  Mass spectrometry characterization of the glycation sites of bovine insulin by tandem mass spectrometry.

Authors:  Sofia Guedes; Rui Vitorino; M Rosário M Domingues; Francisco Amado; Pedro Domingues
Journal:  J Am Soc Mass Spectrom       Date:  2009-03-13       Impact factor: 3.109

7.  Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E.

Authors:  F Fiory; A Lombardi; C Miele; J Giudicelli; F Beguinot; E Van Obberghen
Journal:  Diabetologia       Date:  2011-08-23       Impact factor: 10.122

8.  Preliminary evidence for obesity-associated insulin resistance in adolescents without elevations of inflammatory cytokines.

Authors:  Jessica I Cohen; Lawrence Maayan; Antonio Convit
Journal:  Diabetol Metab Syndr       Date:  2012-06-08       Impact factor: 3.320

9.  Prenatal dietary load of Maillard reaction products combined with postnatal Coca-Cola drinking affects metabolic status of female Wistar rats.

Authors:  Radana Gurecká; Ivana Koborová; Katarína Janšáková; Tamás Tábi; Éva Szökő; Veronika Somoza; Katarína Šebeková; Peter Celec
Journal:  Croat Med J       Date:  2015-04       Impact factor: 1.351

10.  Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improving mitochondrial function and suppressing prolonged AMPK activation.

Authors:  Tien-Jyun Chang; Hsing-Chi Tseng; Meng-Wei Liu; Yi-Cheng Chang; Meng-Lun Hsieh; Lee-Ming Chuang
Journal:  Sci Rep       Date:  2016-03-21       Impact factor: 4.379
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