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Literature DB >> 18792765

TGF-beta and regulatory T cell in immunity and autoimmunity.

Abstract

INTRODUCTION: The immune response is controlled by several inhibitory mechanisms. These mechanisms include regulatory T cells, which exist in multiple classes. Notable among these are Foxp3-expressing regulatory T cells (Treg), NKT cells, and Tr1 cells. Common to these mechanisms are inhibitory cytokines such as interleukin-10 and transforming growth factor-beta (TGF-beta). TGF-beta and Foxp3-expressing Treg cells are critical in maintaining self-tolerance and immune homeostasis. DISCUSSIONS: The immune suppressive functions of TGF-beta and Treg cells are widely acknowledged and extensively studied. Nonetheless, recent studies revealed the positive roles for TGF-beta and Treg cells in shaping the immune system and the inflammatory responses. In this paper, we will discuss the role of these mechanisms in the control of immunity and autoimmunity and the mechanisms that underlie how these molecules control these responses.

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Year: 2008 PMID： 18792765 PMCID： PMC2837280 DOI： 10.1007/s10875-008-9251-y

Source DB: PubMed Journal: J Clin Immunol ISSN： 0271-9142 Impact factor: 8.317

151 in total

1. Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription.

Authors: M E Engel; M A McDonnell; B K Law; H L Moses
Journal: J Biol Chem Date: 1999-12-24 Impact factor: 5.157

2. TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses.

Authors: Li Yu; Mindy C Hébert; Ying E Zhang
Journal: EMBO J Date: 2002-07-15 Impact factor: 11.598

Review 3. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.

Authors: T R Mosmann; R L Coffman
Journal: Annu Rev Immunol Date: 1989 Impact factor: 28.527

4. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease.

Authors: L Gorelik; R A Flavell
Journal: Immunity Date: 2000-02 Impact factor: 31.745

5. Transforming growth factor-beta1 suppresses interleukin-15-mediated interferon-gamma production in human T lymphocytes.

Authors: H Bönig; U Banning; M Hannen; Y M Kim; J Verheyen; C Mauz-Körholz; D Körholz
Journal: Scand J Immunol Date: 1999-12 Impact factor: 3.487

Review 6. CD4+ CD25+ suppressor T cells: more questions than answers.

Authors: Ethan M Shevach
Journal: Nat Rev Immunol Date: 2002-06 Impact factor: 53.106

7. Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

Authors: J H Kehrl; A B Roberts; L M Wakefield; S Jakowlew; M B Sporn; A S Fauci
Journal: J Immunol Date: 1986-12-15 Impact factor: 5.422

8. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor.

Authors: P J Lucas; S J Kim; S J Melby; R E Gress
Journal: J Exp Med Date: 2000-04-03 Impact factor: 14.307

9. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

Authors: J H Kehrl; L M Wakefield; A B Roberts; S Jakowlew; M Alvarez-Mon; R Derynck; M B Sporn; A S Fauci
Journal: J Exp Med Date: 1986-05-01 Impact factor: 14.307

10. Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

Authors: G E Ranges; I S Figari; T Espevik; M A Palladino
Journal: J Exp Med Date: 1987-10-01 Impact factor: 14.307

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Review 5. Inflammation and colorectal cancer: colitis-associated neoplasia.

Authors: Sergei I Grivennikov
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