Literature DB >> 18792693

Inhibitors targeting two-component signal transduction.

Takafumi Watanabe1, Ario Okada, Yasuhiro Gotoh, Ryutaro Utsumi.   

Abstract

A two-component signal transduction system (TCS) is an attractive target for antibacterial agents. In this chapter, we review the TCS inhibitors developed during the past decade and introduce novel drug discovery systems to isolate the inhibitors of the YycG/YycF system, an essential TCS for bacterial growth, in an effort to develop a new class of antibacterial agents.

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Year:  2008        PMID： 18792693     DOI： 10.1007/978-0-387-78885-2_16

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  16 in total

1.  Development and validation of a high-throughput cell-based screen to identify activators of a bacterial two-component signal transduction system.

Authors:  Julia J van Rensburg; Kate R Fortney; Lan Chen; Andrew J Krieger; Bruno P Lima; Alan J Wolfe; Barry P Katz; Zhong-Yin Zhang; Stanley M Spinola
Journal:  Antimicrob Agents Chemother       Date:  2015-04-13       Impact factor: 5.191

2.  Development of an antivirulence drug against Streptococcus mutans: repression of biofilm formation, acid tolerance, and competence by a histidine kinase inhibitor, walkmycin C.

Authors:  Yoko Eguchi; Norihiro Kubo; Hiroko Matsunaga; Masayuki Igarashi; Ryutaro Utsumi
Journal:  Antimicrob Agents Chemother       Date:  2011-01-31       Impact factor: 5.191

3.  Crystallographic characterization of a multidomain histidine protein kinase from an essential two-component regulatory system.

Authors:  Haiyan Zhao; Liang Tang
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-03-21

4.  Preliminary crystallographic studies of the regulatory domain of response regulator YycF from an essential two-component signal transduction system.

Authors:  Haiyan Zhao; Annie Heroux; Reuben D Sequeira; Liang Tang
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-06-27

5.  Computational and experimental analyses reveal the essential roles of interdomain linkers in the biological function of chemotaxis histidine kinase CheA.

Authors:  Xiqing Wang; Chun Wu; Anh Vu; Joan-Emma Shea; Frederick W Dahlquist
Journal:  J Am Chem Soc       Date:  2012-09-21       Impact factor: 15.419

Review 6.  Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era.

Authors:  Maria Kostakioti; Maria Hadjifrangiskou; Scott J Hultgren
Journal:  Cold Spring Harb Perspect Med       Date:  2013-04-01       Impact factor: 6.915

Review 7.  Essential Two-Component Systems Regulating Cell Envelope Functions: Opportunities for Novel Antibiotic Therapies.

Authors:  Silvia T Cardona; Matthew Choy; Andrew M Hogan
Journal:  J Membr Biol       Date:  2017-11-02       Impact factor: 1.843

8.  DnaJ and ClpX Are Required for HitRS and HssRS Two-Component System Signaling in Bacillus anthracis.

Authors:  Clare L Laut; Catherine S Leasure; Hualiang Pi; Sophia M Carlin; Michelle L Chu; Gideon H Hillebrand; Hannah K Lin; Xinjie I Yi; Devin L Stauff; Eric P Skaar
Journal:  Infect Immun       Date:  2021-11-08       Impact factor: 3.609

9.  Targeting a bacterial stress response to enhance antibiotic action.

Authors:  Samuel Lee; Aaron Hinz; Elizabeth Bauerle; Angus Angermeyer; Katy Juhaszova; Yukihiro Kaneko; Pradeep K Singh; Colin Manoil
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-12       Impact factor: 11.205

10.  The linker between the dimerization and catalytic domains of the CheA histidine kinase propagates changes in structure and dynamics that are important for enzymatic activity.

Authors:  Xiqing Wang; Pramodh Vallurupalli; Anh Vu; Kwangwoon Lee; Sheng Sun; Wen-Ju Bai; Chun Wu; Hongjun Zhou; Joan-Emma Shea; Lewis E Kay; Frederick W Dahlquist
Journal:  Biochemistry       Date:  2014-01-28       Impact factor: 3.162
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