Literature DB >> 187923

The location of the feedback-specific region with the pyrimidine-3 locus of Neurospora crassa.

A J Makoff, A Radford.   

Abstract

The purimidine-3 locus of Neurospora crassa specifies two enzyme activities, pyrimidine-specific carbamyl phosphate synthetase (CPSpyr) and aspartate transcarbamylase (ATC). ATC is translationally distal. CPSpyr, but not ATC, is subject to feedback inhibition by uridine triphosphate (UTP). To investigate the location of the feedback-specific region within the locus, inhibition of a number of pyr-3 alleles by UTP was investigated. All CPS+ ATC- polar alleles, revertants of CPS- ATC- polar alleles, and 5-fluorouracil-resistant mutants had normal UTP response. The location of the feedback-specific region is in or close to the CPS-specific region.

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Year:  1976        PMID： 187923     DOI： 10.1007/bf00701247

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  17 in total

1.  The enzymology of control by feedback inhibition.

Authors:  J C GERHART; A B PARDEE
Journal:  J Biol Chem       Date:  1962-03       Impact factor: 5.157

2.  Effect of ornithine, IMP, and UMP on carbamyl phosphate synthetase from Escherichia coli.

Authors:  P M Anderson; S V Marvin
Journal:  Biochem Biophys Res Commun       Date:  1968-09-30       Impact factor: 3.575

3.  Modified methods for the determination of carbamyl aspartate.

Authors:  L M Prescott; M E Jones
Journal:  Anal Biochem       Date:  1969-12       Impact factor: 3.365

4.  Polarised complementation at the pyrimidine-3 locus of Neurospora.

Authors:  A Radford
Journal:  Mol Gen Genet       Date:  1969-07-03

5.  Control of Escherichia coli carbamyl phosphate synthetase by purine and pyrimidine nucleotides.

Authors:  P M Anderson; A Meister
Journal:  Biochemistry       Date:  1966-10       Impact factor: 3.162

6.  Copurification of pyrimidine-specific carbamyl phosphate synthetase and aspartate transcarbamylase of Neurospora crassa.

Authors:  L G Williams; S Bernhardt; R H Davis
Journal:  Biochemistry       Date:  1970-10-27       Impact factor: 3.162

7.  Intragenic mapping of the Neurospora pyrimidine-3 locus by functional deletions.

Authors:  A Radford
Journal:  Mol Gen Genet       Date:  1970

8.  The biosynthesis of carbamoyl phosphate in Saccharomyces cerevisiae.

Authors:  F Lacroute; A Piérard; M Grenson; J M Wiame
Journal:  J Gen Microbiol       Date:  1965-07

9.  Aggregation states of a regulatory enzyme complex catalyzing the early steps of pyrimidine biosynthesis in bakers' yeast.

Authors:  P F Lue; J G Kaplan
Journal:  Can J Biochem       Date:  1971-04

10.  Regulation of pyrimidine biosynthesis in Saccharomyces cerevisiae.

Authors:  F Lacroute
Journal:  J Bacteriol       Date:  1968-03       Impact factor: 3.490
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  3 in total

1.  A possible model for the structure of the Neurospora carbamoyl phosphate synthase-aspartate carbamoyl transferase complex enzyme.

Authors:  A J Makoff; F P Buxton; A Radford
Journal:  Mol Gen Genet       Date:  1978-05-31

Review 2.  Genetics and biochemistry of carbamoyl phosphate biosynthesis and its utilization in the pyrimidine biosynthetic pathway.

Authors:  A J Makoff; A Radford
Journal:  Microbiol Rev       Date:  1978-06

3.  Glutamine utilization in both the arginine-specific and pyrimidine-specific carbamoyl phosphate synthase enzymes of eurospora crassa.

Authors:  A J Makoff; A Radford
Journal:  Mol Gen Genet       Date:  1976-12-08
  3 in total

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