| Literature DB >> 18792114 |
Adam Langenbacher1, Jau-Nian Chen.
Abstract
The establishment of a left-right axis during vertebrate development is essential for coordinating the relative positions of the internal organs to ensure that they function appropriately. Studies in numerous model organisms have revealed differences in regulative mechanisms upstream of nodal signaling, a conserved pathway in left-right axis specification. This review will summarize the diverse pathways involved in the break of left-right symmetry and explore in depth the multiple roles of calcium in vertebrate left-right axis specification. (c) 2008 Wiley-Liss, Inc.Entities:
Mesh:
Year: 2008 PMID: 18792114 PMCID: PMC2836160 DOI: 10.1002/dvdy.21704
Source DB: PubMed Journal: Dev Dyn ISSN: 1058-8388 Impact factor: 3.780