Adrenal incidentaloma: effects on bone metabolism.

The effects of clinically inapparent adrenal masses or adrenal incidentalomas (AI) on bone metabolism are a controversial clinical problem related to their activity. Most of these lesions are non-functioning tumors and only a small percentage of patients exhibits a subclinical hypercortisolism (SH). The degree of clinical appearance of SH varies with the extent of hormone overproduction. However, it is controversial, up to now, if this disorder is associated with long-term morbidity and if the treatment to reverse subtle glucocorticoid excess is beneficial. Patients with AI represent an ideal field to evaluate if alterations of bone turnover may be considered a precocious sign of an abnormal pattern of endogenous steroid secretion. Several small trials have highlighted in AI with and without SH reduced levels of osteocalcin (OC), probably due to a reducted bone formation induced by a subtle excess of glucocorticoids. In patients with AI with and without SH low levels of OC might be considered a precocious sign of an abnormal pattern of slight cortisol hypersecretion and could become one of the pivotal criteria to decide whether these tumors deserve surgical excision.