| Literature DB >> 18790643 |
Dongmei Han1, F Holger Försterling, Xiaoyan Li, Jeffrey R Deschamps, Damon Parrish, Hui Cao, Sundari Rallapalli, Terry Clayton, Yun Teng, Samarpan Majumder, Subramaniam Sankar, Bryan L Roth, Werner Sieghart, Roman Furtmuller, James K Rowlett, Michael R Weed, James M Cook.
Abstract
The stable conformations of GABA(A)-benzodiazepine receptor bivalent ligands were determined by low temperature NMR spectroscopy and confirmed by single crystal X-ray analysis. The stable conformations in solution correlated well with those in the solid state. The linear conformation was important for these dimers to access the binding site and exhibit potent in vitro affinity and was illustrated for alpha5 subtype selective ligands. Bivalent ligands with an oxygen-containing linker folded back upon themselves both in solution and the solid state. Dimers which are folded do not bind to Bz receptors.Entities:
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Year: 2008 PMID： 18790643 PMCID： PMC3703926 DOI： 10.1016/j.bmc.2008.08.072
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641