Literature DB >> 18790090

Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice.

Hironobu Nakane1, Seiichi Hirota, Philip J Brooks, Yusaku Nakabeppu, Yoshimichi Nakatsu, Yoshitake Nishimune, Akihiro Iino, Kiyoji Tanaka.   

Abstract

We have reported that xeroderma pigmentosum group A (Xpa) gene-knockout mice [Xpa (-/-) mice] are deficient in nucleotide excision repair (NER) and highly sensitive to UV-induced skin carcinogenesis. Although xeroderma pigmentosum group A patients show growth retardation, immature sexual development, and neurological abnormalities as well as a high incidence of UV-induced skin tumors, Xpa (-/-) mice were physiologically and behaviorally normal. In the present study, we kept Xpa (-/-) mice for 2 years under specific pathogen-free (SPF) conditions and found that the testis diminished in an age-dependent manner, and degenerating seminiferous tubules and no spermatozoa were detected in the 24-month-old Xpa (-/-) mice. In addition, a higher incidence of spontaneous tumorigenesis was observed in the 24-month-old Xpa (-/-) mice compared to Xpa (+/+) controls. Xpa (-/-) mice provide a useful model for investigating the aging and internal tumor formation in XPA patients.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18790090      PMCID： PMC4551480          DOI： 10.1016/j.dnarep.2008.08.003

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  49 in total

1.  Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B.

Authors:  Jessica M Y Ng; Harry Vrieling; Kaoru Sugasawa; Marja P Ooms; J Anton Grootegoed; Jan T M Vreeburg; Pim Visser; Rudolph B Beems; Theo G M F Gorgels; Fumio Hanaoka; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Journal:  Mol Cell Biol       Date:  2002-02       Impact factor: 4.272

2.  The oxidative DNA lesion 8,5'-(S)-cyclo-2'-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells.

Authors:  P J Brooks; D S Wise; D A Berry; J V Kosmoski; M J Smerdon; R L Somers; H Mackie; A Y Spoonde; E J Ackerman; K Coleman; R E Tarone; J H Robbins
Journal:  J Biol Chem       Date:  2000-07-21       Impact factor: 5.157

Review 3.  Hereditary anemias of the mouse: a review for geneticists.

Authors:  E S Russell
Journal:  Adv Genet       Date:  1979       Impact factor: 1.944

4.  Sequence of the mouse XPC cDNA and genomic structure of the human XPC gene.

Authors:  L Li; C Peterson; R Legerski
Journal:  Nucleic Acids Res       Date:  1996-03-15       Impact factor: 16.971

5.  Meiotic pachytene arrest in MLH1-deficient mice.

Authors:  W Edelmann; P E Cohen; M Kane; K Lau; B Morrow; S Bennett; A Umar; T Kunkel; G Cattoretti; R Chaganti; J W Pollard; R D Kolodner; R Kucherlapati
Journal:  Cell       Date:  1996-06-28       Impact factor: 41.582

6.  New functions of XPC in the protection of human skin cells from oxidative damage.

Authors:  Mariarosaria D'Errico; Eleonora Parlanti; Massimo Teson; Bruno M Bernardes de Jesus; Paolo Degan; Angelo Calcagnile; Pawel Jaruga; Magnar Bjørås; Marco Crescenzi; Antonia M Pedrini; Jean-Marc Egly; Giovanna Zambruno; Miria Stefanini; Miral Dizdaroglu; Eugenia Dogliotti
Journal:  EMBO J       Date:  2006-09-07       Impact factor: 11.598

7.  Decreased UV sensitivity, mismatch repair activity and abnormal cell cycle checkpoints in skin cancer cell lines derived from UVB-irradiated XPA-deficient mice.

Authors:  M Ichikawa; H Nakane; G Marra; C Corti; J Jiricny; M Fitch; J M Ford; M Ikejima; T Shimada; M Yoshino; S Takeuchi; Y Nakatsu; K Tanaka
Journal:  Mutat Res       Date:  2000-05-31       Impact factor: 2.433

8.  Repair of propanodeoxyguanosine by nucleotide excision repair in vivo and in vitro.

Authors:  K A Johnson; S P Fink; L J Marnett
Journal:  J Biol Chem       Date:  1997-04-25       Impact factor: 5.157

9.  Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells.

Authors:  Laura J Niedernhofer; J Scott Daniels; Carol A Rouzer; Rachel E Greene; Lawrence J Marnett
Journal:  J Biol Chem       Date:  2003-05-29       Impact factor: 5.157

10.  Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.

Authors:  A de Vries; C T van Oostrom; F M Hofhuis; P M Dortant; R J Berg; F R de Gruijl; P W Wester; C F van Kreijl; P J Capel; H van Steeg; S J Verbeek
Journal:  Nature       Date:  1995-09-14       Impact factor: 49.962
View more
  8 in total

1.  SirT1 is required in the male germ cell for differentiation and fecundity in mice.

Authors:  Eric L Bell; Ippei Nagamori; Eric O Williams; Amanda M Del Rosario; Bryan D Bryson; Nicki Watson; Forest M White; Paolo Sassone-Corsi; Leonard Guarente
Journal:  Development       Date:  2014-08-19       Impact factor: 6.868

2.  Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses.

Authors:  Sabine S Lange; Ella Bedford; Shelley Reh; John P Wittschieben; Steve Carbajal; Donna F Kusewitt; John DiGiovanni; Richard D Wood
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-05       Impact factor: 11.205

3.  The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse.

Authors:  Naoki Watanabe; Shinji Mii; Naoya Asai; Masato Asai; Kaoru Niimi; Kaori Ushida; Takuya Kato; Atsushi Enomoto; Hideshi Ishii; Masahide Takahashi; Yoshiki Murakumo
Journal:  J Biol Chem       Date:  2013-03-05       Impact factor: 5.157

4.  Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology.

Authors:  Dick Jaarsma; Ingrid van der Pluijm; Monique C de Waard; Elize D Haasdijk; Renata Brandt; Marcel Vermeij; Yvonne Rijksen; Alex Maas; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Journal:  PLoS Genet       Date:  2011-12-08       Impact factor: 5.917

5.  Transcriptional consequences of XPA disruption in human cell lines.

Authors:  Mandira Manandhar; Megan G Lowery; Karen S Boulware; Kevin H Lin; Yue Lu; Richard D Wood
Journal:  DNA Repair (Amst)       Date:  2017-06-29

6.  Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice.

Authors:  Monique C de Waard; Ingrid van der Pluijm; Nils Zuiderveen Borgesius; Laura H Comley; Elize D Haasdijk; Yvonne Rijksen; Yanto Ridwan; Gerben Zondag; Jan H J Hoeijmakers; Ype Elgersma; Thomas H Gillingwater; Dick Jaarsma
Journal:  Acta Neuropathol       Date:  2010-07-04       Impact factor: 17.088

7.  Involvement of nucleotide excision and mismatch repair mechanisms in double strand break repair.

Authors:  Ye Zhang; Larry H Rohde; Honglu Wu
Journal:  Curr Genomics       Date:  2009-06       Impact factor: 2.236

8.  TCDD-induced multi- and transgenerational changes in the methylome of male zebrafish gonads.

Authors:  Camille Akemann; Danielle N Meyer; Katherine Gurdziel; Tracie R Baker
Journal:  Environ Epigenet       Date:  2020-09-27
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.