Literature DB >> 18789936

Response regulator YycF essential for bacterial growth: X-ray crystal structure of the DNA-binding domain and its PhoB-like DNA recognition motif.

Toshihide Okajima1, Akihiro Doi, Ario Okada, Yasuhiro Gotoh, Katsuyuki Tanizawa, Ryutaro Utsumi.   

Abstract

A response regulator YycF and its cognate sensor kinase YycG constitute the two-component signal transduction system essential for growth of Gram-positive bacteria with a low GC content. We have determined the X-ray crystal structure of the effector domain of Bacillus subtilis YycF involved in DNA binding. The structure, containing a winged helix-turn-helix motif, was found to be very similar to that of the response regulator PhoB from Escherichia coli. Specific binding of YycF to the PhoB-regulated alkaline phosphatase promoter was also demonstrated.

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Year:  2008        PMID： 18789936     DOI： 10.1016/j.febslet.2008.09.007

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  Preliminary crystallographic studies of the regulatory domain of response regulator YycF from an essential two-component signal transduction system.

Authors:  Haiyan Zhao; Annie Heroux; Reuben D Sequeira; Liang Tang
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-06-27

2.  Expression, purification, crystallization and preliminary X-ray analysis of the DNA-binding domain of a Chlamydia trachomatis OmpR/PhoB-subfamily response regulator homolog, ChxR.

Authors:  John M Hickey; P Scott Hefty; Audrey L Lamb
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-07-25

3.  Involvement of WalK (VicK) phosphatase activity in setting WalR (VicR) response regulator phosphorylation level and limiting cross-talk in Streptococcus pneumoniae D39 cells.

Authors:  Kyle J Wayne; Shuo Li; Krystyna M Kazmierczak; Ho-Ching T Tsui; Malcolm E Winkler
Journal:  Mol Microbiol       Date:  2012-09-27       Impact factor: 3.501

4.  Regulation of virulence by the RevR response regulator in Clostridium perfringens.

Authors:  Thomas J Hiscox; Anjana Chakravorty; Jocelyn M Choo; Kaori Ohtani; Tohru Shimizu; Jackie K Cheung; Julian I Rood
Journal:  Infect Immun       Date:  2011-03-14       Impact factor: 3.441

5.  Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalK.

Authors:  Takafumi Watanabe; Masayuki Igarashi; Toshihide Okajima; Eiji Ishii; Hirokazu Kino; Masaki Hatano; Ryuichi Sawa; Maya Umekita; Tomoyuki Kimura; Sho Okamoto; Yoko Eguchi; Yuzuru Akamatsu; Ryutaro Utsumi
Journal:  Antimicrob Agents Chemother       Date:  2012-04-23       Impact factor: 5.191

6.  ATP forms a stable complex with the essential histidine kinase WalK (YycG) domain.

Authors:  Reha Celikel; Vidya Harini Veldore; Irimpan Mathews; Kevin M Devine; Kottayil I Varughese
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2012-06-15

7.  Mechanistic insight into how multidrug resistant Acinetobacter baumannii response regulator AdeR recognizes an intercistronic region.

Authors:  Yurong Wen; Zhenlin Ouyang; Yue Yu; Xiaorong Zhou; Yingmei Pei; Bart Devreese; Paul G Higgins; Fang Zheng
Journal:  Nucleic Acids Res       Date:  2017-09-19       Impact factor: 16.971

8.  Pneumococcal VncR Strain-Specifically Regulates Capsule Polysaccharide Synthesis.

Authors:  Prachetash Ghosh; Masaud Shah; Subramaniyam Ravichandran; Sang-Sang Park; Hamid Iqbal; Sangdun Choi; Kyeong Kyu Kim; Dong Kwon Rhee
Journal:  Front Microbiol       Date:  2019-10-01       Impact factor: 5.640

9.  Solution structure and tandem DNA recognition of the C-terminal effector domain of PmrA from Klebsiella pneumoniae.

Authors:  Yuan-Chao Lou; Iren Wang; M Rajasekaran; Yi-Fen Kao; Meng-Ru Ho; Shang-Te Danny Hsu; Shan-Ho Chou; Shih-Hsiung Wu; Chinpan Chen
Journal:  Nucleic Acids Res       Date:  2013-12-25       Impact factor: 16.971

10.  Structure of the Response Regulator NsrR from Streptococcus agalactiae, Which Is Involved in Lantibiotic Resistance.

Authors:  Sakshi Khosa; Astrid Hoeppner; Holger Gohlke; Lutz Schmitt; Sander H J Smits
Journal:  PLoS One       Date:  2016-03-01       Impact factor: 3.240
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