Literature DB >> 18789935

Alcohol and nicotine consumption exacerbates choroidal neovascularization by modulating the regulation of complement system.

Sankaranarayanan Kaliappan1, Purushottam Jha, Valeriy V Lyzogubov, Ruslana G Tytarenko, Nalini S Bora, Puran S Bora.   

Abstract

The objective of the present study was to investigate the effect of alcohol and nicotine consumption on the pathogenesis of choroidal neovascularization (CNV) in rats after laser-photocoagulation. Confocal microscopic analysis demonstrated an increase in CNV complex size in rats fed with alcohol (2.3-fold), nicotine (1.9-fold), and the combination of alcohol and nicotine (2.7-fold) compared with the control groups. Immunohistochemical analysis revealed that alcohol and nicotine consumption increased MAC deposition and VEGF expression in laser spots. Expression of CD59 by RT-PCR and Western blot was drastically reduced in the animals that were fed with alcohol, nicotine and alcohol and nicotine compared to those fed with water alone and this was associated with exacerbation of CNV.

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Year:  2008        PMID： 18789935      PMCID： PMC2987649          DOI： 10.1016/j.febslet.2008.09.009

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  39 in total

1.  Microarray analysis of nicotine-induced changes in gene expression in endothelial cells.

Authors:  S Zhang; I N Day; S Ye
Journal:  Physiol Genomics       Date:  2001-04-27       Impact factor: 3.107

2.  Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis.

Authors:  C Heeschen; J J Jang; M Weis; A Pathak; S Kaji; R S Hu; P S Tsao; F L Johnson; J P Cooke
Journal:  Nat Med       Date:  2001-07       Impact factor: 53.440

3.  Activation of hypoxia inducible factor-1alpha in gastric mucosa in response to ethanol injury: a trigger for angiogenesis?

Authors:  I L Szabo; H Kawanaka; M K Jones; R Pai; B A Soreghan; D Baatar; S S Husain; A S Tarnawski
Journal:  Life Sci       Date:  2001-11-09       Impact factor: 5.037

4.  Acute ethanol increases angiogenic growth factor gene expression in rat skeletal muscle.

Authors:  Timothy P Gavin; Peter D Wagner
Journal:  J Appl Physiol (1985)       Date:  2002-03

5.  Moderate levels of ethanol induce expression of vascular endothelial growth factor and stimulate angiogenesis.

Authors:  J W Gu; J Elam; A Sartin; W Li; R Roach; T H Adair
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2001-07       Impact factor: 3.619

6.  Cigarette smoke induces rapid changes in gene expression in pulmonary arteries.

Authors:  Joanne L Wright; Hsin Tai; Jin Dai; Andrew Churg
Journal:  Lab Invest       Date:  2002-10       Impact factor: 5.662

Review 7.  Retinal and choroidal neovascularization.

Authors:  P A Campochiaro
Journal:  J Cell Physiol       Date:  2000-09       Impact factor: 6.384

8.  Nicotine and cotinine up-regulate vascular endothelial growth factor expression in endothelial cells.

Authors:  Brian S Conklin; Weidong Zhao; Dian-Sheng Zhong; Changyi Chen
Journal:  Am J Pathol       Date:  2002-02       Impact factor: 4.307

9.  Complement factor H variant Y402H and basal laminar deposits in exudative age-related macular degeneration.

Authors:  Albrecht Lommatzsch; Pia Hermans; Bernhard Weber; Daniel Pauleikhoff
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2007-08-18       Impact factor: 3.117

Review 10.  Alcohol consumption and the risk of age-related macular degeneration: a systematic review and meta-analysis.

Authors:  Elaine W-T Chong; Andreas J Kreis; Tien Y Wong; Julie A Simpson; Robyn H Guymer
Journal:  Am J Ophthalmol       Date:  2008-02-01       Impact factor: 5.258
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  8 in total

1.  Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization.

Authors:  Juan Liu; Purushottam Jha; Valeriy V Lyzogubov; Ruslana G Tytarenko; Nalini S Bora; Puran S Bora
Journal:  J Biol Chem       Date:  2011-04-22       Impact factor: 5.157

2.  Role of ocular complement factor H in a murine model of choroidal neovascularization.

Authors:  Valeriy V Lyzogubov; Ruslana G Tytarenko; Purushottam Jha; Juan Liu; Nalini S Bora; Puran S Bora
Journal:  Am J Pathol       Date:  2010-09-02       Impact factor: 4.307

3.  Nicotine reduces VEGF-secretion and phagocytotic activity in porcine RPE.

Authors:  Alexa Karina Klettner; Johanna Doths; Johann Roider
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2011-08-21       Impact factor: 3.117

4.  The effect of nicotine on anti-vascular endothelial growth factor therapy in a mouse model of neovascular age-related macular degeneration.

Authors:  Stephen J Davis; Valeriy V Lyzogubov; Ruslana G Tytarenko; Ammar N Safar; Nalini S Bora; Puran S Bora
Journal:  Retina       Date:  2012-06       Impact factor: 4.256

5.  Inhibitory role of adiponectin peptide I on rat choroidal neovascularization.

Authors:  Valeriy V Lyzogubov; Ruslana G Tytarenko; Nalini S Bora; Puran S Bora
Journal:  Biochim Biophys Acta       Date:  2012-05-23

6.  Complement regulatory protein CD46 protects against choroidal neovascularization in mice.

Authors:  Valeriy Lyzogubov; Xiaobo Wu; Purushottam Jha; Ruslana Tytarenko; Michael Triebwasser; Grant Kolar; Paula Bertram; Puran S Bora; John P Atkinson; Nalini S Bora
Journal:  Am J Pathol       Date:  2014-07-11       Impact factor: 4.307

7.  The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype.

Authors:  Valeriy V Lyzogubov; Puran S Bora; Xiaobo Wu; Leah E Horn; Ryan de Roque; Xeniya V Rudolf; John P Atkinson; Nalini S Bora
Journal:  Am J Pathol       Date:  2016-06-11       Impact factor: 4.307

8.  Oxidative stress in retinal pigment epithelium cells increases exosome secretion and promotes angiogenesis in endothelial cells.

Authors:  Sandra Atienzar-Aroca; Miguel Flores-Bellver; Gemma Serrano-Heras; Natalia Martinez-Gil; Jorge M Barcia; Silvia Aparicio; Daniel Perez-Cremades; Jose M Garcia-Verdugo; Manuel Diaz-Llopis; Francisco J Romero; Javier Sancho-Pelluz
Journal:  J Cell Mol Med       Date:  2016-03-21       Impact factor: 5.310
  8 in total

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