Literature DB >> 18789860

Novel BK channel openers containing dehydroabietic acid skeleton: structure-activity relationship for peripheral substituents on ring C.

Yong-Mei Cui1, Eriko Yasutomi, Yuko Otani, Takashi Yoshinaga, Katsutoshi Ido, Kohei Sawada, Tomohiko Ohwada.   

Abstract

A series of dehydroabietic acid (DHAA, 2) derivatives was synthesized and evaluated as BK channel openers in an assay system of CHO-K1 cells expressing hBKalpha channels. Systematic modifications of the peripheral functionality of ring C of DHAA showed that the introduction of a nitro or (thio)urea group in ring C greatly enhanced the BK channel-opening activity.

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Year:  2008        PMID： 18789860     DOI： 10.1016/j.bmcl.2008.08.078

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  The smooth muscle-type β1 subunit potentiates activation by DiBAC4(3) in recombinant BK channels.

Authors:  Cristina Bosch Calero; Elisabet Selga; Ramon Brugada; Fabiana S Scornik; Guillermo J Pérez
Journal:  Channels (Austin)       Date:  2013-12-03       Impact factor: 2.581

2.  Synthesis and Biological Evaluation of Novel Dehydroabietic Acid Derivatives Conjugated with Acyl-Thiourea Peptide Moiety as Antitumor Agents.

Authors:  Le Jin; Hong-En Qu; Xiao-Chao Huang; Ying-Ming Pan; Dong Liang; Zhen-Feng Chen; Heng-Shan Wang; Ye Zhang
Journal:  Int J Mol Sci       Date:  2015-06-26       Impact factor: 5.923

Review 3.  KCNMA1-linked channelopathy.

Authors:  Cole S Bailey; Hans J Moldenhauer; Su Mi Park; Sotirios Keros; Andrea L Meredith
Journal:  J Gen Physiol       Date:  2019-08-19       Impact factor: 4.086

4.  The synthesis of a DHAD/ZnAlTi-LDH composite with advanced UV blocking and antibacterial activity for skin protection.

Authors:  Xinlong Liu; Tingting Hu; Guishan Lin; Xiu Wang; Yu Zhu; Ruizheng Liang; Wengui Duan; Min Wei
Journal:  RSC Adv       Date:  2020-03-06       Impact factor: 3.361

5.  A drug pocket at the lipid bilayer-potassium channel interface.

Authors:  Nina E Ottosson; Malin Silverå Ejneby; Xiongyu Wu; Samira Yazdi; Peter Konradsson; Erik Lindahl; Fredrik Elinder
Journal:  Sci Adv       Date:  2017-10-25       Impact factor: 14.136
  5 in total

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