Literature DB >> 18789806

Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection.

Theophilus S Vijaykumar1, Avindra Nath, Ashok Chauhan.   

Abstract

We report in this study that minimum productive HIV infection in astrocytes (a predominant cell type in brain and persists for the entire life) occurs through endocytosis. The lysosomotropic agent chloroquine enhanced permissiveness of astrocytes to HIV infection possibly by circumventing degradation of endosome-entrapped viral particles. In particular, chloroquine may promote establishment of a stable long term viral reservoir in astrocytes and may eventually facilitate early onset of neurological complications.

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Year:  2008        PMID： 18789806      PMCID： PMC2629354          DOI： 10.1016/j.virol.2008.07.039

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  15 in total

1.  Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection.

Authors:  Kartik Chandran; Nancy J Sullivan; Ute Felbor; Sean P Whelan; James M Cunningham
Journal:  Science       Date:  2005-04-14       Impact factor: 47.728

2.  Endocytic entry of HIV-1.

Authors:  O T Fackler; B M Peterlin
Journal:  Curr Biol       Date:  2000-08-24       Impact factor: 10.834

3.  Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection.

Authors:  Bangdong L Wei; Paul W Denton; Eduardo O'Neill; Tianci Luo; John L Foster; J Victor Garcia
Journal:  J Virol       Date:  2005-05       Impact factor: 5.103

4.  Acceleration of viral replication and up-regulation of cytokine levels by antimalarials: implications in malaria-endemic areas.

Authors:  P Seth; H Mani; A K Singh; K K Banaudha; S Madhavan; G S Sidhu; J P Gaddipati; S N Vogel; R K Maheshwari
Journal:  Am J Trop Med Hyg       Date:  1999-08       Impact factor: 2.345

5.  Direct and quantitative single-cell analysis of human immunodeficiency virus type 1 reactivation from latency.

Authors:  Olaf Kutsch; Etty N Benveniste; George M Shaw; David N Levy
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

6.  The ability of chloroquine to prevent tat-induced cytokine secretion by monocytes is implicated in its in vivo anti-human immunodeficiency virus type 1 activity.

Authors:  Fabienne Rayne; Agnès Vendeville; Anne Bonhoure; Bruno Beaumelle
Journal:  J Virol       Date:  2004-11       Impact factor: 5.103

7.  Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport.

Authors:  Ashok Chauhan; Jadwiga Turchan; Chava Pocernich; Anna Bruce-Keller; Susan Roth; D Allan Butterfield; Eugene O Major; Avindra Nath
Journal:  J Biol Chem       Date:  2003-01-24       Impact factor: 5.157

8.  Temporal patterns of human immunodeficiency virus type 1 transcripts in human fetal astrocytes.

Authors:  C Tornatore; K Meyers; W Atwood; K Conant; E Major
Journal:  J Virol       Date:  1994-01       Impact factor: 5.103

9.  Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts.

Authors:  F R Maxfield
Journal:  J Cell Biol       Date:  1982-11       Impact factor: 10.539

10.  Human immunodeficiency virus type 1 efficiently binds to human fetal astrocytes and induces neuroinflammatory responses independent of infection.

Authors:  Jinliang Li; Galina Bentsman; Mary Jane Potash; David J Volsky
Journal:  BMC Neurosci       Date:  2007-05-12       Impact factor: 3.288
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  29 in total

1.  Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium.

Authors:  Lena Al-Harti; Jeymohan Joseph; Avindra Nath
Journal:  J Neurovirol       Date:  2018-11-05       Impact factor: 2.643

Review 2.  Immune activation and the role of TLRs and TLR agonists in the pathogenesis of HIV-1 infection in the humanized mouse model.

Authors:  J Judy Chang; Marcus Altfeld
Journal:  J Infect Dis       Date:  2013-11       Impact factor: 5.226

3.  Enigma of HIV-1 latent infection in astrocytes: an in-vitro study using protein kinase C agonist as a latency reversing agent.

Authors:  Ashok Chauhan
Journal:  Microbes Infect       Date:  2015-06-02       Impact factor: 2.700

4.  Human immunodeficiency virus-associated dementia: a link between accumulation of viral proteins and neuronal degeneration.

Authors:  Italo Mocchetti; Alessia Bachis; Giuseppe Esposito; Scott R Turner; Francesca Taraballi; Ennio Tasciotti; Mikell Paige; Valeriya Avdoshina
Journal:  Curr Trends Neurol       Date:  2014

5.  IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner.

Authors:  Wei Li; Lisa J Henderson; Eugene O Major; Lena Al-Harthi
Journal:  J Immunol       Date:  2011-05-11       Impact factor: 5.422

6.  Role of β-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes.

Authors:  Srinivas D Narasipura; Lisa J Henderson; Sidney W Fu; Liang Chen; Fatah Kashanchi; Lena Al-Harthi
Journal:  J Virol       Date:  2011-12-07       Impact factor: 5.103

Review 7.  Understanding and controlling chronic immune activation in the HIV-infected patients suppressed on combination antiretroviral therapy.

Authors:  Babafemi Taiwo; Luis Barcena; Randall Tressler
Journal:  Curr HIV/AIDS Rep       Date:  2013-03       Impact factor: 5.071

Review 8.  Interplay between Wnt/β-catenin signaling and HIV: virologic and biologic consequences in the CNS.

Authors:  Lena Al-Harthi
Journal:  J Neuroimmune Pharmacol       Date:  2012-10-13       Impact factor: 4.147

9.  Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner.

Authors:  Rajeev Mehla; Shalmali Bivalkar-Mehla; Ruonan Zhang; Indhira Handy; Helmut Albrecht; Shailendra Giri; Prakash Nagarkatti; Mitzi Nagarkatti; Ashok Chauhan
Journal:  PLoS One       Date:  2010-06-16       Impact factor: 3.240

10.  Perturbation of host nuclear membrane component RanBP2 impairs the nuclear import of human immunodeficiency virus -1 preintegration complex (DNA).

Authors:  Ruonan Zhang; Rajeev Mehla; Ashok Chauhan
Journal:  PLoS One       Date:  2010-12-14       Impact factor: 3.240
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