Subhashini Yaturu1, Justin Rains, Sushil K Jain. 1. Department of Endocrinology, Overton Brooks VA Medical Center/LSUHSC, 510 East Stoner Avenue, 111E, Shreveport, LA 71101-4295, USA. Subhashini.Yaturu@va.gov
Abstract
AIM: Our objective of this study is to investigate the relationship between plasma osteoprotegerin (OPG) levels in type 2 diabetes and its relationship with the insulin resistance, HbA(1c), CRP, and TNF-alpha levels. METHODS: In a cross-sectional study, levels of OPG were determined in 50 subjects with type 2 diabetes and 59 control subjects without diabetes. The OPG levels between the groups were compared and their correlation with insulin resistance, glycemia and inflammatory markers CRP and TNF-alpha was determined. RESULTS: OPG levels were elevated in subjects with diabetes (6.8+/-0.27 pmol/l), compared to control subjects (5.7+/-0.26 pmol/l). OPG levels significantly correlate with insulin, insulin resistance, CRP, and TNF-alpha. CONCLUSION: OPG levels are significantly correlated with insulin resistance and may reflect the proinflammatory state in type 2 diabetes.
AIM: Our objective of this study is to investigate the relationship between plasma osteoprotegerin (OPG) levels in type 2 diabetes and its relationship with the insulin resistance, HbA(1c), CRP, and TNF-alpha levels. METHODS: In a cross-sectional study, levels of OPG were determined in 50 subjects with type 2 diabetes and 59 control subjects without diabetes. The OPG levels between the groups were compared and their correlation with insulin resistance, glycemia and inflammatory markers CRP and TNF-alpha was determined. RESULTS:OPG levels were elevated in subjects with diabetes (6.8+/-0.27 pmol/l), compared to control subjects (5.7+/-0.26 pmol/l). OPG levels significantly correlate with insulin, insulin resistance, CRP, and TNF-alpha. CONCLUSION:OPG levels are significantly correlated with insulin resistance and may reflect the proinflammatory state in type 2 diabetes.
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