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Literature DB >> 18789365

Genetic diversity of Group A Streptococcus M protein: implications for typing and vaccine development.

Pierre R Smeesters¹, Patrick Mardulyn, Anne Vergison, Raphaël Leplae, Laurence Van Melderen.

Abstract

Group A Streptococci (GAS) are classified into 180 emm-types based on the sequence of the amino-terminal hyper-variable region of the M surface protein. The genetic relatedness of the whole surface-exposed part of M was investigated in well-characterized Belgian and Brazilian GAS isolates which belong to different epidemiological and clinical landscapes. Despite a small number of different emm-types and an apparent low diversity in the Belgian isolates (as revealed by the emm-typing method), our data showed that the overall genetic diversity of the M proteins was higher than expected. On the contrary, the M proteins from the Brazilian isolates were genetically highly related. Since M is a multi-functional protein, an analysis of the whole surface-exposed sequence that takes into account the different functional domains may provide tools for typing as well as for analyzing the molecular mechanisms of M virulence or defining vaccine strategies.

Entities: Disease Species

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Year: 2008 PMID： 18789365 DOI： 10.1016/j.vaccine.2008.08.037

Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641

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Cited

23 in total

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