| Literature DB >> 18788743 |
Di Zhu1, Min Lu, Pei Juan Chua, Bin Tan, Fei Wang, Xinhao Yang, Guofu Zhong.
Abstract
A facile stereoselective synthesis of multifunctionalized tetrahydro-1,2-oxazines (THOs) has been achieved by the organocatalyzed asymmetric tandem alpha-aminoxylation/aza-Michael reaction for the C-O/C-N bond formations in moderate to good yields with excellent diastereo- (>99:1 dr) and enantioselectivities (92% to >99% ee).Entities:
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Year: 2008 PMID： 18788743 DOI： 10.1021/ol801864c
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005