Literature DB >> 18788742

Total synthesis of Ciliatamides A-C: stereochemical revision and the natural product-guided synthesis of unnatural analogs.

Jana A Lewis1, R Nathan Daniels, Craig W Lindsley.   

Abstract

The first total synthesis of Ciliatamides A-C was completed, leading to a revision of the reported stereochemistry from (S,S) to the (R,R) enantiomers. Due to the expedited route, a library of over 50 unnatural ciliatamide analogs was also prepared.

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Year:  2008        PMID： 18788742      PMCID： PMC3177603          DOI： 10.1021/ol801842v

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Development of a custom high-throughput preparative liquid chromatography/mass spectrometer platform for the preparative purification and analytical analysis of compound libraries.

Authors:  William Leister; Kimberly Strauss; David Wisnoski; Zhijian Zhao; Craig Lindsley
Journal:  J Comb Chem       Date:  2003 May-Jun

Review 2.  Application of combinatorial chemistry science on modern drug discovery.

Authors:  J Phillip Kennedy; Lyndsey Williams; Thomas M Bridges; R Nathan Daniels; David Weaver; Craig W Lindsley
Journal:  J Comb Chem       Date:  2008-01-26

3.  Total synthesis and biological evaluation of the marine bromopyrrole alkaloid dispyrin: elucidation of discrete molecular targets with therapeutic potential.

Authors:  J Phillip Kennedy; John T Brogan; Craig W Lindsley
Journal:  J Nat Prod       Date:  2008-10       Impact factor: 4.050

4.  Leishmania donovani: an in vitro study of antimony-resistant amphotericin B-sensitive isolates.

Authors:  Abdalla Hassan Sharief; Eltahir Awad Gasim Khalil; Thor G Theander; Arsalan Kharazmi; Samia Ali Omer; Muntasir Eltayeb Ibrahim
Journal:  Exp Parasitol       Date:  2006-05-23       Impact factor: 2.011

5.  Synthesis and biological evaluation of 4-chloro-3, 5-dinitrobenzotrifluoride analogues as antileishmanial agents.

Authors:  K K Pitzer; K A Werbovetz; J J Brendle; J P Scovill
Journal:  J Med Chem       Date:  1998-11-19       Impact factor: 7.446

6.  Ciliatamides A-C, bioactive lipopeptides from the deep-sea sponge Aaptos ciliata.

Authors:  Yoichi Nakao; Shizuka Kawatsu; Chikane Okamoto; Masaaki Okamoto; Yoshitsugu Matsumoto; Shigeki Matsunaga; Rob W M van Soest; Nobuhiro Fusetani
Journal:  J Nat Prod       Date:  2008-02-08       Impact factor: 4.050
  6 in total
  1 in total

1.  Total Synthesis of Hinduchelins A-D, Stereochemical Revision of Hinduchelin A, and Biological Evaluation of Natural and Unnatural Analogues.

Authors:  Elizabeth S Childress; Aaron T Garrison; Jessica R Sheldon; Eric P Skaar; Craig W Lindsley
Journal:  J Org Chem       Date:  2019-05-08       Impact factor: 4.354
  1 in total

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