Min Cheng1, Ling-Ying Wu, Ping Bai, Rong Zhang, Shan Zheng. 1. Department of Gynecological Oncology, Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China. chengfeidao@yahoo.com
Abstract
OBJECTIVE: To investigate the clinicopathologic characteristics, therapy and prognostic factors of small cell carcinoma of the cervix. METHODS: Clinical and pathological data of eight patients were analyzed retrospectively. RESULTS: Eight patients all presented with symptoms of abnormal vaginal bleeding or postcoital spotting. One patient had stage I b1 disease, 2 had stage I b2 disease, 2 had stage II b disease and 3 had stage III b disease. Histopathologic findings showed the small tumor cells had scant cytoplasm, round nuclei, absence of nucleoli, and finely dispersed chromatin. Immunohistochemical findings were positive in 7 cases for neuron-specific enolase. Three patients with stage I b disease and 1 patient with stage III b disease underwent radical hysterectomy and postoperative chemotherapy, with or without radiotherapy, and the survival period was 64, 22, 14 and 6 months respectively. Two patients with stage II b disease and 2 with stage III b disease underwent chemotherapy and radiotherapy, and the survival period was 25, 9, 10 and 5 months respectively. CONCLUSIONS: Immunohistochemical analysis using several kinds of neuroendocrine markers is helpful in establishing the correct diagnosis in addition to focusing on characteristic histopathological features. It is necessary to use comprehensive treatment including surgery, chemotherapy and radiotherapy for patients with small cell carcinoma of the cervix. Chemotherapy may play an important role in the treatment.
OBJECTIVE: To investigate the clinicopathologic characteristics, therapy and prognostic factors of small cell carcinoma of the cervix. METHODS: Clinical and pathological data of eight patients were analyzed retrospectively. RESULTS: Eight patients all presented with symptoms of abnormal vaginal bleeding or postcoital spotting. One patient had stage I b1 disease, 2 had stage I b2 disease, 2 had stage II b disease and 3 had stage III b disease. Histopathologic findings showed the small tumor cells had scant cytoplasm, round nuclei, absence of nucleoli, and finely dispersed chromatin. Immunohistochemical findings were positive in 7 cases for neuron-specific enolase. Three patients with stage I b disease and 1 patient with stage III b disease underwent radical hysterectomy and postoperative chemotherapy, with or without radiotherapy, and the survival period was 64, 22, 14 and 6 months respectively. Two patients with stage II b disease and 2 with stage III b disease underwent chemotherapy and radiotherapy, and the survival period was 25, 9, 10 and 5 months respectively. CONCLUSIONS: Immunohistochemical analysis using several kinds of neuroendocrine markers is helpful in establishing the correct diagnosis in addition to focusing on characteristic histopathological features. It is necessary to use comprehensive treatment including surgery, chemotherapy and radiotherapy for patients with small cell carcinoma of the cervix. Chemotherapy may play an important role in the treatment.