PURPOSE: It is believed that estrogen deficiency contributes importantly to the pathogenesis of menopausal metabolic syndrome and symptoms can be ameliorated with estradiol therapy. The present study reports efficacy of 17-beta estradiol encapsulated nanoparticles in treating the postmenopausal dyslipidemic condition. MATERIALS AND METHODS: Estradiol encapsulated poly(lactide-co-glycolide) (PLGA) nanoparticles were prepared by emulsion-diffusion-evaporation method and evaluated in estrogen deficient (ovariectomized) high fat diet induced hyperlipidemic rat model. RESULTS: The results obtained showed that estradiol nanoparticles were equally/more effective in treatment of estrogen deficient hyperlipidemic conditions at three times reduced dose and frequency in comparison to that of drug suspension administered orally. CONCLUSION: Together, these results demonstrate the ability of nanoparticles in improving oral bioavailability/efficacy of estradiol.
PURPOSE: It is believed that estrogen deficiency contributes importantly to the pathogenesis of menopausal metabolic syndrome and symptoms can be ameliorated with estradiol therapy. The present study reports efficacy of 17-beta estradiol encapsulated nanoparticles in treating the postmenopausal dyslipidemic condition. MATERIALS AND METHODS:Estradiol encapsulated poly(lactide-co-glycolide) (PLGA) nanoparticles were prepared by emulsion-diffusion-evaporation method and evaluated in estrogen deficient (ovariectomized) high fat diet induced hyperlipidemic rat model. RESULTS: The results obtained showed that estradiol nanoparticles were equally/more effective in treatment of estrogen deficient hyperlipidemic conditions at three times reduced dose and frequency in comparison to that of drug suspension administered orally. CONCLUSION: Together, these results demonstrate the ability of nanoparticles in improving oral bioavailability/efficacy of estradiol.
Authors: P Parini; B Angelin; A Stavréus-Evers; B Freyschuss; H Eriksson; M Rudling Journal: Arterioscler Thromb Vasc Biol Date: 2000-07 Impact factor: 8.311
Authors: Ebenezer I O Ajayi; Olorunfemi R Molehin; Alex E Iyoha; Divya S P Tallapragada; Omotade I Oloyede; Kulbhushan B Tikoo Journal: IBRO Neurosci Rep Date: 2021-10-09