Marc Leone1, Claude Martin. 1. Service d'anesthésie et de réanimation, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille, Université de la Méditerranée, Marseille, France. marc.leone@ap-hm.fr
Abstract
PURPOSE OF REVIEW: To review the new findings on the use of antibiotics in the ICU patients. RECENT FINDINGS: Although there are several lines of evidence for a prompt use of antibiotics in life-threatening infections, restricting the use of antibiotics should remain the common rule. In order to reduce the emergence of multiresistant bacteria, several approaches have been tested: knowledge of local ecology, choice of the best dose of antibiotics based on their pharmacokinetic and pharmacodynamic properties, de-escalation after results of cultures, and shortening the duration of treatment. An integrative strategy including all these approaches could be associated with a reduced incidence of multiresistant bacteria. SUMMARY: Good evidence suggests that a strategy aiming at reducing the prolonged use of broad-spectrum antibiotics is the only mean to reduce the emergence of multiresistant bacteria.
PURPOSE OF REVIEW: To review the new findings on the use of antibiotics in the ICU patients. RECENT FINDINGS: Although there are several lines of evidence for a prompt use of antibiotics in life-threatening infections, restricting the use of antibiotics should remain the common rule. In order to reduce the emergence of multiresistant bacteria, several approaches have been tested: knowledge of local ecology, choice of the best dose of antibiotics based on their pharmacokinetic and pharmacodynamic properties, de-escalation after results of cultures, and shortening the duration of treatment. An integrative strategy including all these approaches could be associated with a reduced incidence of multiresistant bacteria. SUMMARY: Good evidence suggests that a strategy aiming at reducing the prolonged use of broad-spectrum antibiotics is the only mean to reduce the emergence of multiresistant bacteria.
Authors: A-F Dureau; G Duclos; F Antonini; D Boumaza; N Cassir; J Alingrin; C Vigne; E Hammad; L Zieleskiewicz; M Leone Journal: Eur J Clin Microbiol Infect Dis Date: 2016-10-07 Impact factor: 3.267
Authors: Marc Leone; François Malavieille; Laurent Papazian; Bertrand Meyssignac; Nadim Cassir; Julien Textoris; François Antonini; Bernard La Scola; Claude Martin; Bernard Allaouchiche; Sami Hraiech Journal: Crit Care Date: 2013-08-06 Impact factor: 9.097