| Literature DB >> 18786638 |
Carmen Díaz-Ruiz1, Rosanna Parlato, Fernando Aguado, Jesús M Ureña, Ferran Burgaya, Albert Martínez, Maria A Carmona, Grzegorz Kreiner, Susanne Bleckmann, Jose A Del Río, Günther Schütz, Eduardo Soriano.
Abstract
The family of CREB transcription factors is involved in a variety of biological processes including the development and plasticity of the nervous system. To gain further insight into the roles of CREB family members in the development of the embryonic brain, we examined the migratory phenotype of CREB1(Nescre)CREM(-/-) mutants. We found that the lack of CREB/CREM genes is accompanied by anatomical defects in specific layers of the olfactory bulb, hippocampus and cerebral cortex. These changes are associated with decreased Dab1 expression in CREB1(Nescre)CREM(-/-) mutants. Our results indicate that the lack of CREB/CREM genes, specifically in neural and glial progenitors, leads to migration abnormalities during brain development, suggesting that unidentified age-dependent factors modulate the role of CREB/CREM genes in neural development.Entities:
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Year: 2008 PMID： 18786638 DOI： 10.1016/j.mcn.2008.07.019
Source DB: PubMed Journal: Mol Cell Neurosci ISSN： 1044-7431 Impact factor: 4.314