Literature DB >> 18785726

Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile.

Jianyong Chen1, Gregory T Collins, Jian Zhang, Chao-Yie Yang, Beth Levant, James Woods, Shaomeng Wang.   

Abstract

A series of compounds structurally related to pramipexole were designed, synthesized, and evaluated as ligands for the dopamine 3 (D3) receptor. Compound 12 has a K(i) value of 0.41 nM to D3 and a selectivity of >30000- and 800-fold over the D1-like and D2 receptors, respectively. Our in vivo functional assays showed that this compound is a partial agonist at the D3 receptor with no detectable activity at the D2 receptor.

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Year:  2008        PMID： 18785726      PMCID： PMC2662387          DOI： 10.1021/jm800471h

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  32 in total

1.  Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents.

Authors:  Peter Grundt; Katherine M Prevatt; Jianjing Cao; Michelle Taylor; Christina Z Floresca; Ji-Kyung Choi; Bruce G Jenkins; Robert R Luedtke; Amy Hauck Newman
Journal:  J Med Chem       Date:  2007-08-02       Impact factor: 7.446

2.  Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands.

Authors:  Ke Ding; Jianyong Chen; Min Ji; Xihan Wu; Judith Varady; Chao-Yie Yang; Yipin Lu; Jeffrey R Deschamps; Beth Levant; Shaomeng Wang
Journal:  J Med Chem       Date:  2005-05-05       Impact factor: 7.446

Review 3.  Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents.

Authors:  Amy Hauck Newman; Peter Grundt; Michael A Nader
Journal:  J Med Chem       Date:  2005-06-02       Impact factor: 7.446

4.  High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

Authors:  Vadim Cherezov; Daniel M Rosenbaum; Michael A Hanson; Søren G F Rasmussen; Foon Sun Thian; Tong Sun Kobilka; Hee-Jung Choi; Peter Kuhn; William I Weis; Brian K Kobilka; Raymond C Stevens
Journal:  Science       Date:  2007-10-25       Impact factor: 47.728

5.  Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility.

Authors:  Jianyong Chen; Ke Ding; Beth Levant; Shaomeng Wang
Journal:  Bioorg Med Chem Lett       Date:  2005-11-14       Impact factor: 2.823

6.  Dopamine D(3) receptor antagonists. 1. Synthesis and structure-activity relationships of 5,6-dimethoxy-N-alkyl- and N-alkylaryl-substituted 2-aminoindans.

Authors:  S R Haadsma-Svensson; K A Cleek; D M Dinh; J N Duncan; C L Haber; R M Huff; M E Lajiness; N F Nichols; M W Smith; K A Svensson; M J Zaya; A Carlsson; C H Lin
Journal:  J Med Chem       Date:  2001-12-20       Impact factor: 7.446

Review 7.  Dopamine D3 receptor as a therapeutic target for antipsychotic and antiparkinsonian drugs.

Authors:  J N Joyce
Journal:  Pharmacol Ther       Date:  2001 May-Jun       Impact factor: 12.310

8.  Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype.

Authors:  M J Robarge; S M Husbands; A Kieltyka; R Brodbeck; A Thurkauf; A H Newman
Journal:  J Med Chem       Date:  2001-09-13       Impact factor: 7.446

9.  Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.

Authors:  Søren G F Rasmussen; Hee-Jung Choi; Daniel M Rosenbaum; Tong Sun Kobilka; Foon Sun Thian; Patricia C Edwards; Manfred Burghammer; Venkata R P Ratnala; Ruslan Sanishvili; Robert F Fischetti; Gebhard F X Schertler; William I Weis; Brian K Kobilka
Journal:  Nature       Date:  2007-10-21       Impact factor: 49.962

10.  Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists.

Authors:  Gregory T Collins; Amy Hauck Newman; Peter Grundt; Kenner C Rice; Stephen M Husbands; Cédric Chauvignac; Jianyong Chen; Shaomeng Wang; James H Woods
Journal:  Psychopharmacology (Berl)       Date:  2007-03-29       Impact factor: 4.530
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  13 in total

1.  CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist.

Authors:  Jianyong Chen; Gregory T Collins; Beth Levant; James Woods; Jeffrey R Deschamps; Shaomeng Wang
Journal:  ACS Med Chem Lett       Date:  2011-08-11       Impact factor: 4.345

Review 2.  Advances and challenges in the search for D2 and D3 dopamine receptor-selective compounds.

Authors:  Amy E Moritz; R Benjamin Free; David R Sibley
Journal:  Cell Signal       Date:  2017-07-14       Impact factor: 4.315

3.  High-affinity and selective dopamine D₃ receptor full agonists.

Authors:  Jianyong Chen; Beth Levant; Shaomeng Wang
Journal:  Bioorg Med Chem Lett       Date:  2012-07-11       Impact factor: 2.823

4.  Synthesis and pharmacological evaluation of fluorine-containing D₃ dopamine receptor ligands.

Authors:  Zhude Tu; Shihong Li; Jinquan Cui; Jinbin Xu; Michelle Taylor; David Ho; Robert R Luedtke; Robert H Mach
Journal:  J Med Chem       Date:  2011-02-24       Impact factor: 7.446

5.  In Silico Studies Targeting G-protein Coupled Receptors for Drug Research Against Parkinson's Disease.

Authors:  Agostinho Lemos; Rita Melo; Antonio Jose Preto; Jose Guilherme Almeida; Irina Sousa Moreira; Maria Natalia Dias Soeiro Cordeiro
Journal:  Curr Neuropharmacol       Date:  2018       Impact factor: 7.363

Review 6.  Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders.

Authors:  Christian A Heidbreder; Amy H Newman
Journal:  Ann N Y Acad Sci       Date:  2010-02       Impact factor: 5.691

7.  Synthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D3 dopamine receptor selective ligands.

Authors:  Zhude Tu; Shihong Li; Aixiao Li; Michelle Taylor; David Ho; Maninder Malik; Robert R Luedtke; Robert H Mach
Journal:  Medchemcomm       Date:  2013-09       Impact factor: 3.597

8.  Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on L-dopa dependent animal involuntary movements in rats.

Authors:  Lindsay R Riddle; Rakesh Kumar; Suzy A Griffin; Peter Grundt; Amy Hauck Newman; Robert R Luedtke
Journal:  Neuropharmacology       Date:  2010-09-17       Impact factor: 5.250

9.  Narrowing in on compulsions: dopamine receptor functions.

Authors:  Gregory T Collins; James H Woods
Journal:  Exp Clin Psychopharmacol       Date:  2008-12       Impact factor: 3.157

10.  N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.

Authors:  Amy Hauck Newman; Peter Grundt; George Cyriac; Jeffrey R Deschamps; Michelle Taylor; Rakesh Kumar; David Ho; Robert R Luedtke
Journal:  J Med Chem       Date:  2009-04-23       Impact factor: 7.446
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