Literature DB >> 18785046

Solubility properties of chlorhexidine salts.

Pengyung Zeng1, Aruna Rao, Timothy Scott Wiedmann, Walter Bowles.   

Abstract

Chlorhexidine (CHX) is effective in treating oral bacterial infections. The solubility was shown to be highly dependent on the salt present in solution. Gluconate enhances the amount of CHX diacetate in solution possibly through mixed micelles formation, because the solubility product is such that the concentration of CHX will exceed the critical micelle concentration. However, only low concentrations of CHX dichloride can be obtained, which is not appreciably solubilized by gluconate ions. The low concentration of CHX that can be achieved in physiological concentrations of chloride in the oral cavity may be problematic for dental, slow release formulations.

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Year:  2009        PMID： 18785046     DOI： 10.1080/03639040802220318

Source DB:  PubMed          Journal:  Drug Dev Ind Pharm        ISSN： 0363-9045            Impact factor:   3.225


  12 in total

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3.  Chlorhexidine salt-loaded polyurethane orthodontic chains: in vitro release and antibacterial activity studies.

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5.  Influencing factors on gelatin matrix for chlorhexidine delivery.

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7.  Novel Chlorhexidine-Loaded Polymeric Nanoparticles for Root Canal Treatment.

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9.  Electrospun Bioresorbable Membrane Eluting Chlorhexidine for Dental Implants.

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Review 10.  Recent Advances in Indirect Pulp Treatment Materials for Primary Teeth: A Literature Review.

Authors:  Afnan M Saber; Omar A El Meligy; Sumer M Alaki
Journal:  Int J Clin Pediatr Dent       Date:  2021 Nov-Dec
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