PURPOSE: To assess telomere DNA content (TC) and the number of sites of allelic imbalance (AI) as a function of breast cancer progression. EXPERIMENTAL DESIGN: TC and AI were determined in 54 histologically normal tissues, 10 atypical ductal hyperplasias (ADH), 122 in situ ductal carcinomas (DCIS) and 535 invasive carcinomas (Stage I-IIIA). RESULTS: TC was altered in ADH lesions (20%), DCIS specimens (53%) and invasive carcinomas (51%). The mean number of sites of AI was 0.26 in histologically normal group tissue, increased to 1.00 in ADH, 2.94 in DCIS, and 3.07 in invasive carcinomas. All groups were statistically different from the histologically normal group (P < 0.001 for each); however, there was no difference between DCIS and the invasive groups. CONCLUSIONS: Genomic instability increases in ADH and plateaus in DCIS without further increase in the invasive carcinomas, supporting the notion that invasive carcinomas evolve from or in parallel with DCIS.
PURPOSE: To assess telomere DNA content (TC) and the number of sites of allelic imbalance (AI) as a function of breast cancer progression. EXPERIMENTAL DESIGN:TC and AI were determined in 54 histologically normal tissues, 10 atypical ductal hyperplasias (ADH), 122 in situ ductal carcinomas (DCIS) and 535 invasive carcinomas (Stage I-IIIA). RESULTS:TC was altered in ADH lesions (20%), DCIS specimens (53%) and invasive carcinomas (51%). The mean number of sites of AI was 0.26 in histologically normal group tissue, increased to 1.00 in ADH, 2.94 in DCIS, and 3.07 in invasive carcinomas. All groups were statistically different from the histologically normal group (P < 0.001 for each); however, there was no difference between DCIS and the invasive groups. CONCLUSIONS: Genomic instability increases in ADH and plateaus in DCIS without further increase in the invasive carcinomas, supporting the notion that invasive carcinomas evolve from or in parallel with DCIS.
Authors: R K Moyzis; J M Buckingham; L S Cram; M Dani; L L Deaven; M D Jones; J Meyne; R L Ratliff; J R Wu Journal: Proc Natl Acad Sci U S A Date: 1988-09 Impact factor: 11.205
Authors: N W Kim; M A Piatyszek; K R Prowse; C B Harley; M D West; P L Ho; G M Coviello; W E Wright; S L Weinrich; J W Shay Journal: Science Date: 1994-12-23 Impact factor: 47.728
Authors: Hiromi Tanaka; Satoshi Abe; Nazmul Huda; LiRen Tu; Matthew J Beam; Brenda Grimes; David Gilley Journal: Proc Natl Acad Sci U S A Date: 2012-08-13 Impact factor: 11.205
Authors: Chiara Maria Mazzanti; Mohammad Al Hamad; Giovanni Fanelli; Cristian Scatena; Francesca Zammarchi; Katia Zavaglia; Francesca Lessi; Mauro Pistello; Antonio Giuseppe Naccarato; Generoso Bevilacqua Journal: Am J Pathol Date: 2011-08-18 Impact factor: 4.307