Literature DB >> 18784829

Stability and autolysis of cortical neurons in post-mortem adult rat brains.

Sergey V Sheleg1, Janine R Lobello, Hugh Hixon, Stephen W Coons, David Lowry, Mikhail K Nedzved.   

Abstract

We investigated the dynamics of autolytic damage of the cortical neurons in adult brains for 24 hours at room temperature (+20 degrees C) after cardiac arrest. The progressive histological and ultrastructural changes were documented using routine and immunohistochemical staining as well as electron microscopy. Our results demonstrated that there were no autolytic damages in the ultrastructure of cerebral neurons in the first 6 hours after warm cardiac arrest, in agreement with previous studies in other mammals. Interestingly, the activation of caspase-3 was observed in a significant number of neurons of the cerebellum and neocortex 9 hours following cardiac arrest. No significant changes related to autolysis were observed using amnio-cupric acid and Nissl (thionine) staining.

Entities:  

Keywords:  Brain death; apoptosis; autolysis; caspase-3; cerebral anoxia; cerebral hypoxia

Year:  2008        PMID： 18784829      PMCID： PMC2480568     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  28 in total

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4.  Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells.

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5.  A clinico-neuropathological study on brain death.

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7.  Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia.

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8.  Recovery of a 62-year-old man from prolonged cold water submersion.

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9.  In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes.

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Authors:  J S de Olmos; C A Beltramino; S de Olmos de Lorenzo
Journal:  Neurotoxicol Teratol       Date:  1994 Nov-Dec       Impact factor: 3.763
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2.  The influences of morphine or ketamine pre-treatment on hemodynamic, acid-base status, biochemical markers of brain damage and early survival in rats after asphyxial cardiac arrest.

Authors:  Vladimir Kuklin; Nurlan Akhatov; Timofei Kondratiev; Aidos Konkayev; Abai Baigenzhin; Maiya Konkayeva; Temirlan Karibekov; Nicholas Barlow; Torkjel Tveita; Vegard Dahl
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  2 in total

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