BACKGROUND: Blast injuries are becoming more common in modern war and terrorist action. This increasing threat underscores the importance of understanding and evaluating blast effects. METHODS: For this study, data on more than 2,550 large animal experiments were collected from more than 50 experimental studies on blast. From this dataset, over 1,100 large animal experiments were selected with positive phase overpressure durations of 30 milliseconds or less. A two variable nonlinear logistic regression was performed on the experimental data for threshold injury and lethality in terms of pressure and duration. The effects of mass, pressure, and duration scaling were all evaluated. RESULTS: New injury risk assessment curves were analyzed for both incident and reflected pressure conditions. Position dependent injury risk curves were also analyzed and were found to be unnecessary, at least for prone and side on conditions. CONCLUSIONS: The injury risk assessment showed good correlation to some of the existing injury assessments. It also showed good correspondence to a reported human case of blast exposure. Pressure scaling was analyzed to be unnecessary for these short duration exposures. Recommended injury assessments for various orientations relative to the incoming blast wave are included.
BACKGROUND: Blast injuries are becoming more common in modern war and terrorist action. This increasing threat underscores the importance of understanding and evaluating blast effects. METHODS: For this study, data on more than 2,550 large animal experiments were collected from more than 50 experimental studies on blast. From this dataset, over 1,100 large animal experiments were selected with positive phase overpressure durations of 30 milliseconds or less. A two variable nonlinear logistic regression was performed on the experimental data for threshold injury and lethality in terms of pressure and duration. The effects of mass, pressure, and duration scaling were all evaluated. RESULTS: New injury risk assessment curves were analyzed for both incident and reflected pressure conditions. Position dependent injury risk curves were also analyzed and were found to be unnecessary, at least for prone and side on conditions. CONCLUSIONS: The injury risk assessment showed good correlation to some of the existing injury assessments. It also showed good correspondence to a reported human case of blast exposure. Pressure scaling was analyzed to be unnecessary for these short duration exposures. Recommended injury assessments for various orientations relative to the incoming blast wave are included.
Authors: Michelle K Nyein; Amanda M Jason; Li Yu; Claudio M Pita; John D Joannopoulos; David F Moore; Raul A Radovitzky Journal: Proc Natl Acad Sci U S A Date: 2010-11-22 Impact factor: 11.205
Authors: Michael K Walls; Nicholas Race; Lingxing Zheng; Sasha M Vega-Alvarez; Glen Acosta; Jonghyuck Park; Riyi Shi Journal: J Neurosurg Date: 2015-08-21 Impact factor: 5.115
Authors: Aurélie Jean; Michelle K Nyein; James Q Zheng; David F Moore; John D Joannopoulos; Raúl Radovitzky Journal: Proc Natl Acad Sci U S A Date: 2014-09-29 Impact factor: 11.205
Authors: Matthew Beamer; Shanti R Tummala; David Gullotti; Catherine Kopil; Samuel Gorka; Cameron R Dale Bass; Barclay Morrison; Akiva S Cohen; David F Meaney Journal: Exp Neurol Date: 2016-05-28 Impact factor: 5.330
Authors: Andrew J Newman; Sarah H Hayes; Abhiram S Rao; Brian L Allman; Senthilvelan Manohar; Dalian Ding; Daniel Stolzberg; Edward Lobarinas; Joseph C Mollendorf; Richard Salvi Journal: J Neurosci Methods Date: 2015-01-15 Impact factor: 2.390
Authors: Sung-Il Cho; Simon S Gao; Anping Xia; Rosalie Wang; Felipe T Salles; Patrick D Raphael; Homer Abaya; Jacqueline Wachtel; Jongmin Baek; David Jacobs; Matthew N Rasband; John S Oghalai Journal: PLoS One Date: 2013-07-01 Impact factor: 3.240