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Literature DB >> 18784467

A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers.

Rae-Anne Hardie¹, Erin Knight, Brigitte Bruneau, Christina Semeniuk, Kulvinder Gill, Nico Nagelkerke, Joshua Kimani, Charles Wachihi, Elizabeth Ngugi, Ma Luo, Francis A Plummer.

Abstract

Human leucocyte antigen-DP presents peptides to CD4 T cells and plays an important role in parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P = 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P = 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
HLA-DP Antigens

Year: 2008 PMID： 18784467 PMCID： PMC2683274 DOI： 10.1097/QAD.0b013e328311d1a0

Source DB: PubMed Journal: AIDS ISSN： 0269-9370 Impact factor: 4.177

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Authors: Philip A Lacap; Janis D Huntington; Ma Luo; Nico J D Nagelkerke; Thomas Bielawny; Joshua Kimani; Charles Wachihi; Elizabeth N Ngugi; Francis A Plummer
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5. A genetic polymorphism of FREM1 is associated with resistance against HIV infection in the Pumwani sex worker cohort.

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