Michael A Kolber1. 1. Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA. mkolber@med.miami.edu
Abstract
OBJECTIVE: Studies have found that CD8 T-cell activation, as measured by CD38 expression, in HIV-1-infected individuals on suppressive therapy for longer than 12 months is not predictive of CD4 T-cell recovery. Owing to the fact that reconstitution of memory and naive T-cell populations occurs differentially over time, this study evaluated whether distinct memory/naive CD4 T-cell subsets correlated with CD38 on CD8 T-cells. MATERIALS AND METHODS: Whole blood from 13 participants was used to evaluate activation phenotypic markers on CD8 lymphocytes and memory/naive phenotypes on CD4 lymphocytes. These HIV-1-infected individuals had stable CD4 cell counts for more than 1 year while on suppressive combination antiretroviral therapy. RESULTS: The results demonstrate that CD4 central memory and naive cell populations contribute to the magnitude of CD4 T-cell reconstitution. CD4 central memory has a significant negative correlation with the percentage of CD38-activated CD8 T-cells. CONCLUSION: This suggests that CD8 activation is important in CD4 recovery from a low CD4 T-cell nadir.
OBJECTIVE: Studies have found that CD8 T-cell activation, as measured by CD38 expression, in HIV-1-infected individuals on suppressive therapy for longer than 12 months is not predictive of CD4 T-cell recovery. Owing to the fact that reconstitution of memory and naive T-cell populations occurs differentially over time, this study evaluated whether distinct memory/naive CD4 T-cell subsets correlated with CD38 on CD8 T-cells. MATERIALS AND METHODS: Whole blood from 13 participants was used to evaluate activation phenotypic markers on CD8 lymphocytes and memory/naive phenotypes on CD4 lymphocytes. These HIV-1-infected individuals had stable CD4 cell counts for more than 1 year while on suppressive combination antiretroviral therapy. RESULTS: The results demonstrate that CD4 central memory and naive cell populations contribute to the magnitude of CD4 T-cell reconstitution. CD4 central memory has a significant negative correlation with the percentage of CD38-activated CD8 T-cells. CONCLUSION: This suggests that CD8 activation is important in CD4 recovery from a low CD4 T-cell nadir.
Authors: Berta Torres; Norma I Rallón; Montserrat Loncá; Alba Díaz; Llucia Alós; Esteban Martínez; Anna Cruceta; Joan Albert Arnaiz; Lorna Leal; Constanza Lucero; Agathe León; Marcelo Sánchez; Eugenia Negredo; Bonaventura Clotet; José M Gatell; José M Benito; Felipe Garcia Journal: AIDS Res Hum Retroviruses Date: 2014-02-10 Impact factor: 2.205
Authors: Rachel E Owen; John W Heitman; Dale F Hirschkorn; Marion C Lanteri; Hope H Biswas; Jeffrey N Martin; Melissa R Krone; Steven G Deeks; Philip J Norris Journal: AIDS Date: 2010-05-15 Impact factor: 4.177