Literature DB >> 18784145

Pro- and anti-fibrotic effects of TGF-beta in scleroderma.

R Sgonc1, G Wick.   

Abstract

The University of California at Davis 200 and 206 (UCD-200/206) lines of chickens have proven to be the animal model that best reflects the situation in human SSc. We have demonstrated a misbalance of pro-fibrotic (TGF-beta1) and anti-fibrotic (TGF-beta2 and -beta3) TGF-beta isoforms as a possible cause for fibrotic alterations in this model. This opens new avenues for diagnosis and therapy for this still intractable condition.

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Year:  2008        PMID： 18784145      PMCID： PMC3292795          DOI： 10.1093/rheumatology/ken275

Source DB:  PubMed          Journal:  Rheumatology (Oxford)        ISSN： 1462-0324            Impact factor:   7.580


  10 in total

Review 1.  Role of transforming growth factor beta in human disease.

Authors:  G C Blobe; W P Schiemann; H F Lodish
Journal:  N Engl J Med       Date:  2000-05-04       Impact factor: 91.245

2.  Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma.

Authors:  R Sgonc; M S Gruschwitz; H Dietrich; H Recheis; M E Gershwin; G Wick
Journal:  J Clin Invest       Date:  1996-08-01       Impact factor: 14.808

Review 3.  Mechanisms and consequences of fibrosis in systemic sclerosis.

Authors:  Christopher P Denton; Carol M Black; David J Abraham
Journal:  Nat Clin Pract Rheumatol       Date:  2006-03

4.  Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192.

Authors:  Christopher P Denton; Peter A Merkel; Daniel E Furst; Dinesh Khanna; Paul Emery; Vivien M Hsu; Nancy Silliman; James Streisand; John Powell; Anita Akesson; John Coppock; Frank van den Hoogen; Ariane Herrick; Maureen D Mayes; Douglas Veale; Joanna Haas; Stephen Ledbetter; Joseph H Korn; Carol M Black; James R Seibold
Journal:  Arthritis Rheum       Date:  2007-01

5.  Diminished transforming growth factor beta2 production leads to increased expression of a profibrotic procollagen alpha2 type I messenger RNA variant in embryonic fibroblasts of UCD-200 chickens, a model for systemic sclerosis.

Authors:  Martina Prelog; Paul Scheidegger; Silvia Peter; M Eric Gershwin; Georg Wick; Roswitha Sgonc
Journal:  Arthritis Rheum       Date:  2005-06

6.  Altered procollagen mRNA expression during the progression of avian scleroderma.

Authors:  M J Ausserlechner; R Sgonc; H Dietrich; G Wick
Journal:  Mol Med       Date:  1997-10       Impact factor: 6.354

7.  Genomic analysis of collagen and endogenous virus loci in the UCD-200 and 206 lines of chickens, animal models for scleroderma.

Authors:  R Sgonc; H Dietrich; M E Gershwin; A Colombatti; G Wick
Journal:  J Autoimmun       Date:  1995-10       Impact factor: 7.094

8.  Cultured fibroblasts in avian scleroderma, an autoimmune fibrotic disease, display an activated phenotype.

Authors:  M R Duncan; T J Wilson; J Van De Water; B Berman; R Boyd; G Wick; M E Gershwin
Journal:  J Autoimmun       Date:  1992-10       Impact factor: 7.094

Review 9.  Scar wars: is TGFbeta the phantom menace in scleroderma?

Authors:  Andrew Leask
Journal:  Arthritis Res Ther       Date:  2006       Impact factor: 5.156

Review 10.  Avian models with spontaneous autoimmune diseases.

Authors:  Georg Wick; Leif Andersson; Karel Hala; M Eric Gershwin; Carlo Selmi; Gisela F Erf; Susan J Lamont; Roswitha Sgonc
Journal:  Adv Immunol       Date:  2006       Impact factor: 3.543
  10 in total
  11 in total

Review 1.  Targeted therapy for systemic sclerosis: how close are we?

Authors:  Manuel Ramos-Casals; Vicent Fonollosa-Pla; Pilar Brito-Zerón; Antoni Sisó-Almirall
Journal:  Nat Rev Rheumatol       Date:  2010-04-13       Impact factor: 20.543

2.  Cross regulation between hypoxia-inducible transcription factor-1α (HIF-1α) and transforming growth factor (TGF)-ß1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis.

Authors:  Fenghua Qian; Mindi He; Weixia Duan; Lin Mao; Qian Li; Zhengping Yu; Zhou Zhou; Yong Zhang
Journal:  Am J Transl Res       Date:  2015-11-15       Impact factor: 4.060

Review 3.  The immunology of fibrosis: innate and adaptive responses.

Authors:  Georg Wick; Aleksandar Backovic; Evelyn Rabensteiner; Nadine Plank; Christian Schwentner; Roswitha Sgonc
Journal:  Trends Immunol       Date:  2010-01-26       Impact factor: 16.687

4.  Searching for a good model for systemic sclerosis: the molecular profile and vascular changes occurring in UCD-200 chickens strongly resemble the early phase of human systemic sclerosis.

Authors:  Paola Cipriani; Paola Di Benedetto; Hermann Dietrich; Piero Ruscitti; Vasiliki Liakouli; Francesco Carubbi; Ilenia Pantano; Onorina Berardicurti; Roswitha Sgonc; Roberto Giacomelli
Journal:  Arch Med Sci       Date:  2016-07-01       Impact factor: 3.318

Review 5.  Cardiac phenotype in mouse models of systemic autoimmunity.

Authors:  Chandan Sanghera; Lok Man Wong; Mona Panahi; Amalia Sintou; Muneer Hasham; Susanne Sattler
Journal:  Dis Model Mech       Date:  2019-03-08       Impact factor: 5.758

6.  Genome-wide analysis using exon arrays demonstrates an important role for expression of extra-cellular matrix, fibrotic control and tissue remodelling genes in Dupuytren's disease.

Authors:  Helen B Forrester; Peter Temple-Smith; Seungmin Ham; David de Kretser; Graeme Southwick; Carl N Sprung
Journal:  PLoS One       Date:  2013-03-12       Impact factor: 3.240

7.  Over, and underexpression of endothelin 1 and TGF-beta family ligands and receptors in lung tissue of broilers with pulmonary hypertension.

Authors:  Norma Dominguez-Avila; Gabriel Ruiz-Castañeda; Javier González-Ramírez; Nora Fernandez-Jaramillo; Jorge Escoto; Fausto Sánchez-Muñoz; Ricardo Marquez-Velasco; Rafael Bojalil; Román Espinosa-Cervantes; Fausto Sánchez
Journal:  Biomed Res Int       Date:  2013-10-28       Impact factor: 3.411

8.  The challenges of dialysis in systemic sclerosis: between the devil and the deep blue sea?

Authors:  N Brown; A Summers; M C Venning; I N Bruce
Journal:  Case Rep Nephrol       Date:  2012-09-10

9.  Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages.

Authors:  Beate M Lichtenberger; Maria Mastrogiannaki; Fiona M Watt
Journal:  Nat Commun       Date:  2016-02-03       Impact factor: 14.919

10.  Effectiveness of rosiglitazone in reducing flexion contracture in a rabbit model of arthrofibrosis with surgical capsular release: A biomechanical, histological, and genetic analysis.

Authors:  J D Barlow; M E Morrey; R U Hartzler; D Arsoy; S Riester; A J van Wijnen; B F Morrey; J Sanchez-Sotelo; M P Abdel
Journal:  Bone Joint Res       Date:  2016-01       Impact factor: 5.853
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