Literature DB >> 18784131

Role of PDGF in fibrotic diseases and systemic sclerosis.

M Trojanowska1.   

Abstract

PDGF functions as a primary mitogen and chemoattractant for cells of mesenchymal origin. Members of the PDGF family play an important role during embryonic development and contribute to the maintenance of connective tissue in adults. Deregulation of PDGF signalling has been linked to atherosclerosis, pulmonary hypertension and organ fibrosis. Elevated expression of PDGF and its receptors has been found in scleroderma skin and lung tissues. There is evidence for a TGF-beta and IL-1alpha-dependent autocrine PDGF-A/PDGFRalpha signalling loop in scleroderma skin and lung fibroblasts, suggesting that a cross-talk between TGF-beta and PDGF pathways may regulate chronic fibrosis in scleroderma.

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Year:  2008        PMID： 18784131     DOI： 10.1093/rheumatology/ken265

Source DB:  PubMed          Journal:  Rheumatology (Oxford)        ISSN： 1462-0324            Impact factor:   7.580


  64 in total

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10.  Platelet-derived growth factor-D promotes fibrogenesis of cardiac fibroblasts.

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