AIMS: To investigate whether lipopolysaccharide binding protein (LBP) level is an early marker of intraamniotic infection in pregnant women with premature rupture of the membranes (PROM) and compare it to C-reactive protein (CRP). METHODS: Seventy-two pregnant women with PROM were included in the study if remained undelivered for more than 24 h. CRP and LBP concentrations were determined in 12-h-intervals and the last value before delivery was correlated with obstetrical data and placenta histology. RESULTS: LBP concentrations ranged from 1.6 to 48.7 microg/mL (median of 16 microg/mL) and CRP concentrations from 0.02 to 6.8 mg/dL (0.64 mg/dL). CRP was significantly elevated when full blown chorioamnionitis was proven by histology (P<0.01) and when the neonates had to be admitted to the intensive care unit because of suspected infection (P<0.05 mg/dL). There were significantly higher LBP levels when fetal tachycardia occurred (20.3 vs. 14.5 microg/mL, P<0.05) and when intraamniotic infection was diagnosed by histology (22.8 vs. 14.1 microg/mL, P<0.005), but the differences were too little to provide prognostic cut-off values. CONCLUSION: Increase of LBP and CRP levels after PROM seem to reflect intramniotic infection, but no cut-off values could be defined for the prediction of intraamniotic infection.
AIMS: To investigate whether lipopolysaccharide binding protein (LBP) level is an early marker of intraamniotic infection in pregnant women with premature rupture of the membranes (PROM) and compare it to C-reactive protein (CRP). METHODS: Seventy-two pregnant women with PROM were included in the study if remained undelivered for more than 24 h. CRP and LBP concentrations were determined in 12-h-intervals and the last value before delivery was correlated with obstetrical data and placenta histology. RESULTS:LBP concentrations ranged from 1.6 to 48.7 microg/mL (median of 16 microg/mL) and CRP concentrations from 0.02 to 6.8 mg/dL (0.64 mg/dL). CRP was significantly elevated when full blown chorioamnionitis was proven by histology (P<0.01) and when the neonates had to be admitted to the intensive care unit because of suspected infection (P<0.05 mg/dL). There were significantly higher LBP levels when fetal tachycardia occurred (20.3 vs. 14.5 microg/mL, P<0.05) and when intraamniotic infection was diagnosed by histology (22.8 vs. 14.1 microg/mL, P<0.005), but the differences were too little to provide prognostic cut-off values. CONCLUSION: Increase of LBP and CRP levels after PROM seem to reflect intramniotic infection, but no cut-off values could be defined for the prediction of intraamniotic infection.
Authors: Chong Jai Kim; Roberto Romero; Juan Pedro Kusanovic; Wonsuk Yoo; Zhong Dong; Vanessa Topping; Francesca Gotsch; Bo Hyun Yoon; Je Geun Chi; Jung-Sun Kim Journal: Mod Pathol Date: 2010-03-26 Impact factor: 7.842
Authors: Vanessa Topping; Roberto Romero; Nandor Gabor Than; Adi L Tarca; Zhonghui Xu; Sun Young Kim; Bing Wang; Lami Yeo; Chong Jai Kim; Sonia S Hassan; Jung-Sun Kim Journal: J Matern Fetal Neonatal Med Date: 2012-11-23