Literature DB >> 18783292

AKT1 (E17K) mutation in pancreatic cancer.

Azim Mohamedali1, Nicholas C Lea, Roger M Feakins, Kavita Raj, Ghulam J Mufti, Hemant M Kocher.   

Abstract

The prevalence of a novel somatic mutation (E17K) in the pleckstrin homology domain of AKT1 was investigated in pancreatic cancer using a quantitative pyrosequencing assay. This mutation was un-detectable in pancreatic cancer tissue samples (n=65) and pancreatic cell line (n=10) DNA suggesting that pancreatic cancer progression is mainly dependent on the K-Ras mutation.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18783292     DOI： 10.1177/153303460800700509

Source DB:  PubMed          Journal:  Technol Cancer Res Treat        ISSN： 1533-0338


  9 in total

Review 1.  Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy.

Authors:  Jiao Zhang; Yan-Hua Chen; Qun Lu
Journal:  Future Oncol       Date:  2010-04       Impact factor: 3.404

Review 2.  Regulation of Akt signaling activation by ubiquitination.

Authors:  Wei-Lei Yang; Ching-Yuan Wu; Juan Wu; Hui-Kuan Lin
Journal:  Cell Cycle       Date:  2010-02-01       Impact factor: 4.534

3.  The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas.

Authors:  K Shoji; K Oda; S Nakagawa; S Hosokawa; G Nagae; Y Uehara; K Sone; Y Miyamoto; H Hiraike; O Hiraike-Wada; T Nei; K Kawana; H Kuramoto; H Aburatani; T Yano; Y Taketani
Journal:  Br J Cancer       Date:  2009-06-02       Impact factor: 7.640

4.  Loss of PTEN expression is associated with poor prognosis in patients with intraductal papillary mucinous neoplasms of the pancreas.

Authors:  Dario Garcia-Carracedo; Andrew T Turk; Stuart A Fine; Nathan Akhavan; Benjamin C Tweel; Ramon Parsons; John A Chabot; John D Allendorf; Jeanine M Genkinger; Helen E Remotti; Gloria H Su
Journal:  Clin Cancer Res       Date:  2013-10-16       Impact factor: 12.531

5.  Cancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domain.

Authors:  Ambuj Kumar; Rituraj Purohit
Journal:  PLoS One       Date:  2013-05-31       Impact factor: 3.240

6.  K63-linked ubiquitination in kinase activation and cancer.

Authors:  Guocan Wang; Yuan Gao; Liren Li; Guoxiang Jin; Zhen Cai; Jui-I Chao; Hui-Kuan Lin
Journal:  Front Oncol       Date:  2012-01-31       Impact factor: 6.244

7.  Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma.

Authors:  Neetu Kalra; Jingli Zhang; Anish Thomas; Liqiang Xi; Mitchell Cheung; Jacqueline Talarchek; Sandra Burkett; Maria G Tsokos; Yuanbin Chen; Mark Raffeld; Markku Miettinen; Ira Pastan; Joseph R Testa; Raffit Hassan
Journal:  BMC Cancer       Date:  2015-05-08       Impact factor: 4.430

8.  Mutant AKT1-E17K is oncogenic in lung epithelial cells.

Authors:  Carmela De Marco; Donatella Malanga; Nicola Rinaldo; Fernanda De Vita; Marianna Scrima; Sara Lovisa; Linda Fabris; Maria Vincenza Carriero; Renato Franco; Antonia Rizzuto; Gustavo Baldassarre; Giuseppe Viglietto
Journal:  Oncotarget       Date:  2015-11-24

Review 9.  Metabolism addiction in pancreatic cancer.

Authors:  R Blum; Y Kloog
Journal:  Cell Death Dis       Date:  2014-02-20       Impact factor: 8.469
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.