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Literature DB >> 18783225

Addressing mechanistic issues in the coupling of isonitriles and carboxylic acids: potential routes to peptidic constructs.

Xuechen Li¹, Yu Yuan, Cindy Kan, Samuel J Danishefsky.

Abstract

Mechanistic issues surrounding the two component coupling (2CC) reaction of carboxylic acids with isonitriles have been investigated. Experimental details suggest the formimidate carboxylate mixed anhydride intermediate exists in both interdictable and noninterdictable form. Furthermore, the 2CC reaction has been applied to the synthesis of a tripeptide featuring two formyl functional groups.

Entities: Chemical Disease Gene Species

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Year: 2008 PMID： 18783225 PMCID： PMC2580816 DOI： 10.1021/ja804709s

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

13 in total

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6. Enhancing the scope of the Diels-Alder reaction through isonitrile chemistry: emergence of a new class of acyl-activated dienophiles.

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