| Literature DB >> 18783207 |
Daniele Simoni1, Romeo Romagnoli, Riccardo Baruchello, Riccardo Rondanin, Giuseppina Grisolia, Marco Eleopra, Michele Rizzi, Manlio Tolomeo, Giuseppe Giannini, Domenico Alloatti, Massimo Castorina, Marcella Marcellini, Claudio Pisano.
Abstract
A novel class of combretastatins, modified at A-ring or both A- and B-rings, mainly by replacement with benzofuran or benzo[b]thiophene, were synthesized. The new heterocombretastatins showed good cytotoxic activity on BMEC and H-460 cell lines. The aminocombretastatin 9f potently inhibits cell growth of BMEC and combretastatin-resistant HT-29 cell lines, with potential interest to treat colon carcinoma. Heterocombretastatins 9a,b inhibit tubulin polymerization similarly to CA-4 by having a binding to colchicine site five times stronger.Entities:
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Year: 2008 PMID： 18783207 DOI： 10.1021/jm8005004
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446