CONTEXT: The efficacy of treatments for pediatric obesity remains unclear. OBJECTIVE: We performed a systematic review of randomized trials to estimate the efficacy of nonsurgical interventions for pediatric obesity. DATA SOURCES: Librarian-designed search strategies of nine electronic databases from inception until February 2006, review of reference lists from published reviews, and content expert advice provided potentially eligible studies. STUDY SELECTION: Eligible studies were randomized trials of overweight children and adolescents assessing the effect of nonsurgical interventions on obesity outcomes. DATA EXTRACTION: Independently and in duplicate, reviewers assessed the quality of each trial and collected data on interventions and outcomes. DATA SYNTHESIS: Of 76 eligible trials, 61 had complete data for meta-analysis. Short-term medications were effective, including sibutramine [random-effects pooled estimate of body mass index (BMI) loss of 2.4 kg/m(2) with a 95% confidence interval (CI) of 1.8-3.1; proportion of between-study inconsistency not due to chance (I(2)) = 30%] and orlistat (BMI loss = 0.7 kg/m(2); CI = 0.3-1.2; I(2) = 0%). Trials that measured the effect of physical activity on adiposity (i.e. percent body fat and fat-free mass) found a moderate treatment effect (effect size = -0.52; CI = -0.73 to -0.30; I(2) = 0%), whereas trials measuring the effect on BMI found no significant effect (effect size = -0.02; CI = -0.21 to 0.18; I(2) = 0%), but reporting bias may explain this finding. Combined lifestyle interventions (24 trials) led to small changes in BMI. CONCLUSIONS: Limited evidence supports the short-term efficacy of medications and lifestyle interventions. The long-term efficacy and safety of pediatric obesity treatments remain unclear.
CONTEXT: The efficacy of treatments for pediatric obesity remains unclear. OBJECTIVE: We performed a systematic review of randomized trials to estimate the efficacy of nonsurgical interventions for pediatric obesity. DATA SOURCES: Librarian-designed search strategies of nine electronic databases from inception until February 2006, review of reference lists from published reviews, and content expert advice provided potentially eligible studies. STUDY SELECTION: Eligible studies were randomized trials of overweight children and adolescents assessing the effect of nonsurgical interventions on obesity outcomes. DATA EXTRACTION: Independently and in duplicate, reviewers assessed the quality of each trial and collected data on interventions and outcomes. DATA SYNTHESIS: Of 76 eligible trials, 61 had complete data for meta-analysis. Short-term medications were effective, including sibutramine [random-effects pooled estimate of body mass index (BMI) loss of 2.4 kg/m(2) with a 95% confidence interval (CI) of 1.8-3.1; proportion of between-study inconsistency not due to chance (I(2)) = 30%] and orlistat (BMI loss = 0.7 kg/m(2); CI = 0.3-1.2; I(2) = 0%). Trials that measured the effect of physical activity on adiposity (i.e. percent body fat and fat-free mass) found a moderate treatment effect (effect size = -0.52; CI = -0.73 to -0.30; I(2) = 0%), whereas trials measuring the effect on BMI found no significant effect (effect size = -0.02; CI = -0.21 to 0.18; I(2) = 0%), but reporting bias may explain this finding. Combined lifestyle interventions (24 trials) led to small changes in BMI. CONCLUSIONS: Limited evidence supports the short-term efficacy of medications and lifestyle interventions. The long-term efficacy and safety of pediatric obesity treatments remain unclear.
Authors: Robert I Berkowitz; Margaret R Rukstalis; Chanelle T Bishop-Gilyard; Reneé H Moore; Christine A Gehrman; Melissa S Xanthopoulos; William J Cochran; Delroy Louden; Thomas A Wadden Journal: J Pediatr Psychol Date: 2013-06-08
Authors: Gina L Tripicchio; Alice S Ammerman; Cody Neshteruk; Myles S Faith; Kelsey Dean; Christie Befort; Dianne S Ward; Kimberly P Truesdale; Kyle S Burger; Ann Davis Journal: Child Obes Date: 2017-07-20 Impact factor: 2.992
Authors: Nazrat M Mirza; Matilde G Palmer; Kelly B Sinclair; Robert McCarter; Jianping He; Cara B Ebbeling; David S Ludwig; Jack A Yanovski Journal: Am J Clin Nutr Date: 2012-12-19 Impact factor: 7.045
Authors: Kristine A Madsen; Andrea K Garber; Michele L Mietus-Snyder; Joan K Orrell-Valente; Cam-Tu Tran; Lidya Wlasiuk; Renee I Matos; John Neuhaus; Robert H Lustig Journal: J Pediatr Endocrinol Metab Date: 2009-09 Impact factor: 1.634