AIM: Large variations in results of diagnostic tests for mild to moderate dry eye are widely recognised. The purpose of this study was to assess if there was concordance between common dry eye diagnostic tests. METHODS: A total of 91 subjects were recruited to the study. The tear film and ocular surface were evaluated using the phenol red thread test (PRT), tear film break-up time (TBUT), biomicroscopic examination and impression cytological assessment of conjunctival goblet cells. Dry eye symptoms were assessed using McMonnies' dry eye questionnaire (MQ) and statistical correlations between all tests were assessed. RESULTS: This study cohort did not include severe aqueous deficient dry eye patients as determined by the PRT. A statistically significant difference was noted between PRT results and all other tests (p<or=0.001). Only Meibomian gland pathology, MQ, reduced goblet cell density and TBUT (<or=7 s) demonstrated correlation determined by McNemar's test. CONCLUSION: A correlation was found only between tests assessing lipid/mucous deficiency (Meibomian gland evaluation, goblet cell density, TBUT and MQ).
AIM: Large variations in results of diagnostic tests for mild to moderate dry eye are widely recognised. The purpose of this study was to assess if there was concordance between common dry eye diagnostic tests. METHODS: A total of 91 subjects were recruited to the study. The tear film and ocular surface were evaluated using the phenol red thread test (PRT), tear film break-up time (TBUT), biomicroscopic examination and impression cytological assessment of conjunctival goblet cells. Dry eye symptoms were assessed using McMonnies' dry eye questionnaire (MQ) and statistical correlations between all tests were assessed. RESULTS: This study cohort did not include severe aqueous deficient dry eyepatients as determined by the PRT. A statistically significant difference was noted between PRT results and all other tests (p<or=0.001). Only Meibomian gland pathology, MQ, reduced goblet cell density and TBUT (<or=7 s) demonstrated correlation determined by McNemar's test. CONCLUSION: A correlation was found only between tests assessing lipid/mucous deficiency (Meibomian gland evaluation, goblet cell density, TBUT and MQ).
Authors: Yoshimi Suzukamo; Tetsuro Oshika; Mitsuko Yuzawa; Yoshihiro Tokuda; Atsuo Tomidokoro; Kotaro Oki; Carol M Mangione; Joseph Green; Shunichi Fukuhara Journal: Health Qual Life Outcomes Date: 2005-10-26 Impact factor: 3.186
Authors: Roni M Shtein; Daniel E Harper; Vincent Pallazola; Steven E Harte; Munira Hussain; Alan Sugar; David A Williams; Daniel J Clauw Journal: Trans Am Ophthalmol Soc Date: 2016-08
Authors: Amalia Enríquez-de-Salamanca; Evangelina Castellanos; Michael E Stern; Itziar Fernández; Ester Carreño; Carmen García-Vázquez; Jose M Herreras; Margarita Calonge Journal: Mol Vis Date: 2010-05-19 Impact factor: 2.367
Authors: Oriana M Bezzina; Peter Gallagher; Sheryl Mitchell; Simon J Bowman; Bridget Griffiths; Victoria Hindmarsh; Ben Hargreaves; Elizabeth J Price; Colin T Pease; Paul Emery; Peter Lanyon; Michele Bombardieri; Nurhan Sutcliffe; Costantino Pitzalis; John Hunter; Monica Gupta; John McLaren; Anne M Cooper; Marian Regan; Ian P Giles; David A Isenberg; Vadivelu Saravanan; David Coady; Bhaskar Dasgupta; Neil J McHugh; Steven A Young-Min; Robert J Moots; Nagui Gendi; Mohammed Akil; Kirsten MacKay; W Fai Ng; Lucy J Robinson Journal: Arthritis Care Res (Hoboken) Date: 2017-10-09 Impact factor: 4.794