OBJECTIVE: Patients with a primary neurodegenerative disorder associated with cognitive impairment are at increased risk for epilepsy. The goal of the present study was to characterize seizure type(s), etiological diagnosis of dementia, electroencephalogram (EEG) and imaging findings, and response to antiepileptic drug (AED) therapy in these individuals. METHODS: A retrospective study was performed identifying patients in the Mayo Alzheimer Disease Patient Registry (ADPR) and Alzheimer Disease Research Center (ADRC) who were classified as having dementia and epilepsy from 1986 to 2006. Multiple clinical parameters were extracted from patient charts and evaluated to characterize the primary neurodegenerative disorder and seizure outcomes. RESULTS: Sixty-three of the 1738 ADPR and ADRC patients (3.6%) had epilepsy. Twenty-four of the 63 patients were excluded because of insufficient information regarding their epilepsy. The remaining 39 patients were analyzed. Twenty-eight of the 63 patients (72%) experienced complex partial seizures. Head MRI was performed in 35 patients (90%). Fourteen patients (36%) had MRI-identified structural lesions that included remote stroke and prior intracerebral hemorrhage. EEGs were obtained in 29 patients (74%). Fifteen patients (38%) had epileptiform discharges. Overall, it was found that 79% had an excellent response to AED therapy. Approximately one-third of the patients had dose-related side effects from an AED. CONCLUSION: The present study indicated that most individuals with the comorbidity of epilepsy and dementia have complex partial seizures that may be adequately controlled on AED therapy. The long-term effect of seizure activity on the neurodegenerative disorder is unknown.
OBJECTIVE:Patients with a primary neurodegenerative disorder associated with cognitive impairment are at increased risk for epilepsy. The goal of the present study was to characterize seizure type(s), etiological diagnosis of dementia, electroencephalogram (EEG) and imaging findings, and response to antiepileptic drug (AED) therapy in these individuals. METHODS: A retrospective study was performed identifying patients in the MayoAlzheimer DiseasePatient Registry (ADPR) and Alzheimer Disease Research Center (ADRC) who were classified as having dementia and epilepsy from 1986 to 2006. Multiple clinical parameters were extracted from patient charts and evaluated to characterize the primary neurodegenerative disorder and seizure outcomes. RESULTS: Sixty-three of the 1738 ADPR and ADRC patients (3.6%) had epilepsy. Twenty-four of the 63 patients were excluded because of insufficient information regarding their epilepsy. The remaining 39 patients were analyzed. Twenty-eight of the 63 patients (72%) experienced complex partial seizures. Head MRI was performed in 35 patients (90%). Fourteen patients (36%) had MRI-identified structural lesions that included remote stroke and prior intracerebral hemorrhage. EEGs were obtained in 29 patients (74%). Fifteen patients (38%) had epileptiform discharges. Overall, it was found that 79% had an excellent response to AED therapy. Approximately one-third of the patients had dose-related side effects from an AED. CONCLUSION: The present study indicated that most individuals with the comorbidity of epilepsy and dementia have complex partial seizures that may be adequately controlled on AED therapy. The long-term effect of seizure activity on the neurodegenerative disorder is unknown.
Authors: Carlos Velez-Pardo; Jon I Arellano; Patricia Cardona-Gomez; Marlene Jimenez Del Rio; Francisco Lopera; Javier De Felipe Journal: Epilepsia Date: 2004-07 Impact factor: 5.864
Authors: J Garrard; J Cloyd; C Gross; N Hardie; L Thomas; T Lackner; N Graves; I Leppik Journal: J Gerontol A Biol Sci Med Sci Date: 2000-07 Impact factor: 6.053
Authors: James B Leverenz; Christina M Agustin; Debby Tsuang; Elaine R Peskind; Steven D Edland; David Nochlin; Lillian DiGiacomo; James D Bowen; Wayne C McCormick; Linda Teri; Murray A Raskind; Walter A Kukull; Eric B Larson Journal: Arch Neurol Date: 2002-07
Authors: K J Hatanpaa; D M Blass; O Pletnikova; B J Crain; E H Bigio; J C Hedreen; C L White; J C Troncoso Journal: Neurology Date: 2004-08-10 Impact factor: 9.910
Authors: Keith A Vossel; Alexander J Beagle; Gil D Rabinovici; Huidy Shu; Suzee E Lee; Georges Naasan; Manu Hegde; Susannah B Cornes; Maya L Henry; Alexandra B Nelson; William W Seeley; Michael D Geschwind; Maria L Gorno-Tempini; Tina Shih; Heidi E Kirsch; Paul A Garcia; Bruce L Miller; Lennart Mucke Journal: JAMA Neurol Date: 2013-09-01 Impact factor: 18.302
Authors: Willem Huijbers; Aaron P Schultz; Kathryn V Papp; Molly R LaPoint; Bernard Hanseeuw; Jasmeer P Chhatwal; Trey Hedden; Keith A Johnson; Reisa A Sperling Journal: J Neurosci Date: 2018-11-27 Impact factor: 6.167