Literature DB >> 18782566

Interaction of USF1/USF2 and alpha-Pal/Nrf1 to Fmr-1 promoter increases in mouse brain during aging.

S Prasad1, Kanchan Singh.   

Abstract

Fragile X syndrome is caused due to silencing of FMR-1 gene transcription leading to loss of fragile X mental retardation protein (FMRP). To investigate whether the transcriptional mechanism is linked to aging, we have studied interaction of the transcription factors USF1/USF2 and alpha-Pal/Nrf1 to E-box and GC-box, respectively, in Fmr-1 promoter in the brain of young, adult, and old mouse using electrophoretic mobility shift assay (EMSA). Our data reveal that the interaction of these transcription factors to their respective promoter sequences increases in mouse brain as a function of age. The finding on the interaction of the above transcription factors to their cognate sequences is novel as the current investigation has been carried out in intact and aging mouse. The present finding is important in respect to age- and FMRP-dependent brain function.

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Year:  2008        PMID： 18782566     DOI： 10.1016/j.bbrc.2008.08.155

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

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Authors:  Sarika Singh; M K Thakur
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Journal:  J Biol Chem       Date:  2017-05-18       Impact factor: 5.157

3.  Differential regulation of GLT-1/EAAT2 gene expression by NF-κB and N-myc in male mouse brain during postnatal development.

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Journal:  Neurochem Res       Date:  2013-11-26       Impact factor: 3.996

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5.  Repulsive parallel MCMC algorithm for discovering diverse motifs from large sequence sets.

Authors:  Hisaki Ikebata; Ryo Yoshida
Journal:  Bioinformatics       Date:  2015-01-11       Impact factor: 6.937

6.  Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.

Authors:  Hao Zhang; Yang Zhang; Xinyue Zhou; Shaela Wright; Judith Hyle; Lianzhong Zhao; Jie An; Xujie Zhao; Ying Shao; Beisi Xu; Hyeong-Min Lee; Taosheng Chen; Yang Zhou; Xiang Chen; Rui Lu; Chunliang Li
Journal:  Elife       Date:  2020-10-01       Impact factor: 8.140
  6 in total

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