Literature DB >> 18782562

Striatal 19S Rpt6 deficit is related to alpha-synuclein accumulation in MPTP-treated mice.

Bin Liu1, Qiaoqiao Shi, Shiping Ma, Nan Feng, Jiang Li, Ling Wang, Xiaoliang Wang.   

Abstract

Striatal mitochondrial proteins were investigated using proteomics in the 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Four proteins, 19S proteasome ATPase Rpt6 (19S Rpt6), Lectin-related nature killer cell receptor LY 49S, Zinc finger A20 domain containing 1, and the sodium channel-associated protein 1 isoform 2, were significantly decreased while alpha-synuclein was increased in MPTP-treated mice. The altered levels of 19S Rpt6 and alpha-synuclein were further verified by Western blot. Experiments using small interfering RNA (siRNA) showed that alpha-synuclein was increased by 50% in cultured striatal neurons when 19S Rpt6 was knocked down. Taken together, our results imply that a deficiency in 19S Rpt6 may be partially related to the MPTP-induced increase in alpha-synuclein in the striatum.

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Year:  2008        PMID： 18782562     DOI： 10.1016/j.bbrc.2008.08.142

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

Review 1.  Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis.

Authors:  Sharawan Yadav; Anubhuti Dixit; Sonal Agrawal; Ashish Singh; Garima Srivastava; Anand Kumar Singh; Pramod Kumar Srivastava; Om Prakash; Mahendra Pratap Singh
Journal:  Mol Neurobiol       Date:  2012-06-27       Impact factor: 5.590

2.  Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.

Authors:  Elaine L Pranski; Carson D Van Sanford; Nirjari V Dalal; Adam L Orr; Dipan Karmali; Deborah S Cooper; Nichole Costa; Craig J Heilman; Marla Gearing; James J Lah; Allan I Levey; Ranjita S Betarbet
Journal:  Neurosci Lett       Date:  2012-05-23       Impact factor: 3.046

3.  Proteomic profiling in MPTP monkey model for early Parkinson disease biomarker discovery.

Authors:  Xiangmin Lin; Min Shi; Jeyaraj Gunasingh Masilamoni; Romel Dator; James Movius; Patrick Aro; Yoland Smith; Jing Zhang
Journal:  Biochim Biophys Acta       Date:  2015-01-22

4.  Systems biology analysis of the proteomic alterations induced by MPP(+), a Parkinson's disease-related mitochondrial toxin.

Authors:  Chiara Monti; Heather Bondi; Andrea Urbani; Mauro Fasano; Tiziana Alberio
Journal:  Front Cell Neurosci       Date:  2015-02-02       Impact factor: 5.505

5.  Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia.

Authors:  Amani Alghamdi; Julie Vallortigara; David R Howlett; Martin Broadstock; Tibor Hortobágyi; Clive Ballard; Alan J Thomas; John T O'Brien; Dag Aarsland; Johannes Attems; Paul T Francis; David R Whitfield
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

6.  T-Type Ca2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model.

Authors:  Jing Xu; Ichiro Kawahata; Hisanao Izumi; Kohji Fukunaga
Journal:  Int J Mol Sci       Date:  2021-06-08       Impact factor: 5.923
  6 in total

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